Recombinant Mouse ABHD11 Protein (1-307 aa), His-tagged

• Cat.No.: ABHD11-1747M
• Product Overview: Recombinant Mouse ABHD11 Protein (1-307 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length.

Specification

• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 35.6 kDa
• Protein length: 1-307 aa
• AA Sequence: MLRWARAWRVPRGVLGASSPRRLAV PVTFCSSRSSGQENADLRPLPLSYN LLDGDATLPAIVFLHGLFGSKTNFN SLAKAMVQRTGRRVLTVDARNHGDS PHSPDASYEAMSQDLQGLLPQLGLV PCVLVGHSMGGKTAMLLALQRPDVV ERLVVVDISPVGTTPGSHIGAFIAA MKAVEIPEKVPHSQARKLADKQLSS VVKEAGIRQFLLTNLVEVGGRFSWR LNLDTLAQHLDKIMTFPQQREPYSG PTLFLLGGNSTYVQPSHHSEIRRLF PQAQIQTVPNAGHWVHSDKPQDFMD AVTSFLA
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Abhd11 abhydrolase domain containing 11 [ Mus musculus ]
• Official Symbol: ABHD11
• Synonyms: ABHD11; abhydrolase domain containing 11; Wbscr21; 1110054D16Rik; A630008N09Rik
• Gene ID: 68758
• mRNA Refseq: NM_001190437
• Protein Refseq: NP_001177366
• UniProt ID: Q8K4F5

Reviews

07/10/2022

Great work on ELISA with recommended dilution !

06/07/2022

Excellent quality products!

11/06/2021

We are satisfied with the WB results of ABHD11 product.

03/15/2021

After-sales questions were answered in a timely manner. Good!

Q&As

What kind of disease is ABHD a biomarker?

ABHD11 is a potential biomarker of lung adenocarcinoma, and is linked to breast cancer malignancy.

What is the influence of ABHD11 for 2-oxoglutarate in metabolic pathways?

ABHD11 loss or inhibition drives a rapid increase in 2-OG levels by impairing lipoylation of the 2-OG dehydrogenase complex (OGDHc)—the rate limiting step for mitochondrial 2-OG metabolism.

What disease caused by the ABHD11 abnormal?

ABHD11 is one of several genes deleted in Williams–Beuren syndrome, a developmental disorder associated with haploinsufficiency of multiple genes.

What fact suggest that ABHD11 was involved in the maintenance of embryonic stem cell identity?

The results of bioinformatic analysis demonstrated that ABHD11 and ABHD10 were downregulated, while most other ABHD family genes, such as Abhd 1, 3, 5, 6, and 7 were upregulated in OCT4-negative cells.

What is the consequences if knockout ABHD11 gene?

ABHD11 knockout disturbed GSK3β/β-Catenin and ERK signaling transduction; ABHD11 knockout led to the misexpression of key metabolic enzymes related to lipid synthesis, glycolysis, and amino acid metabolism.

What disease often use the ABHD11 as prognostic marker?

The ABHD11 often as a prognostic marker of renal cancer.

Where does the ABHD11 protein express in human body?

Kidney - Transmembrane transport (mainly)

What is the results if the ABHD11 overexpress in yeast?

In yeast, the overexpression of ABHD11 or its yeast homolog causes a reduction in the levels of non-polar lipids.

List at least three cellular components of the ABHD11 protein?

1. plasma membrane, 2. endosome, 3. mitochondrion

What results we got when a study conlcuded that qRT-PCR to show that the ABHD11-AS1 expression level was higher in ovarian cancer tissues than in normal ovarian tissue?

This results suggested that the ABHD11 gene promote cancer cell proliferation, metastasis, and invasion, and inhibit cancer cell apoptosis.