Recombinant Human ADCK3, GST-tagged

• Cat.No.: ADCK3-97H
• Product Overview: Recombinant human ADCK3 (156-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: ADCK3 or aarF domain containing kinase 3 is a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. ADCK3 is involved in coenzyme Q10 synthesis which is essential for proper functioning of the mitochondrial respiratory chain. Expression of ADCK3 is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~83 kDa
• Purity: >75% by densitometry
• Applications: Western Blot
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 ug/ul

Gene Information

• Gene Name: ADCK3 aarF domain containing kinase 3 [ Homo sapiens ]
• Official Symbol: ADCK3
• Synonyms: ADCK3; aarF domain containing kinase 3; CABC1, chaperone, ABC1 activity of bc1 complex homolog (S. pombe) , chaperone, ABC1 activity of bc1 complex like (S. pombe) , chaperone ABC1 (activity of bc1 complex, S.pombe) like; chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog (yeast); COQ8; SCAR9; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog; ARCA2; CABC1; MGC4849
• Gene ID: 56997
• mRNA Refseq: NM_020247
• Protein Refseq: NP_064632
• MIM: 606980
• UniProt ID: Q8NI60
• Chromosome Location: 1q42.11
• Function: ATP binding; kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity, transferring phosphorus-containing groups

Q&As

What are the potential therapeutic applications of ADCK3 protein?

ADCK3 protein may have potential therapeutic applications in various diseases, including Parkinson's disease, breast cancer, and other conditions that are linked to CoQ10 deficiency. It may also be useful as a target for developing drugs that modulate CoQ10 biosynthesis.

Are there any limitations to the use of ADCK3 protein in therapy?

One limitation to the use of ADCK3 protein in therapy is its stability and delivery to the target tissues. It is also unclear whether it can be administered orally or if it needs to be delivered via injection or inhalation. Additionally, more studies are needed to determine its safety, efficacy, and potential interactions with other drugs or medications.

Can ADCK3 protein be used in cancer therapy?

ADCK3 protein has been shown to play a role in cell proliferation and migration and may have a potential role in cancer therapy. However, more studies are needed to determine its safety and efficacy.

What potential therapeutic applications does ADCK3 protein have?

ADCK3 protein has been studied for its potential therapeutic applications in various disorders, including mitochondrial diseases, cancer, and neurodegenerative disorders.

Are there any drugs that target ADCK3 protein?

Currently, there are no drugs that directly target ADCK3 protein. However, there are drugs that indirectly affect the biosynthesis of CoQ10, such as statins, which are commonly used to lower cholesterol levels.

Are there any clinical trials underway that focus on ADCK3 protein?

There are currently no clinical trials underway that focus on ADCK3 protein. However, there are ongoing studies investigating CoQ10 supplementation in various conditions, including heart disease and neurodegenerative disorders.

Is ADCK3 protein only found in humans?

No, ADCK3 protein is found in various species, including humans, mice, rats, and zebrafish.

Are there any risks associated with the use of ADCK3 protein therapeutically?

The use of ADCK3 protein as a therapeutic agent has not been extensively studied, so there may be potential risks and side effects that are not yet known. Additionally, using ADCK3 protein to directly modify CoQ10 levels may not be as effective or safe as other methods of increasing CoQ10 levels, such as taking CoQ10 supplements.

How can ADCK3 protein be used in neurodegenerative disorder therapy?

ADCK3 protein has been shown to play a role in the regulation of cellular stress response pathways and may have a potential role in treating neurodegenerative disorders.

Can ADCK3 protein be used as a biomarker for certain diseases?

Yes, studies have shown that ADCK3 protein levels may be decreased in patients with certain diseases, including Parkinson's disease and breast cancer. Therefore, it may have potential as a biomarker for these diseases.

How can ADCK3 protein be used to treat mitochondrial diseases?

Mitochondrial diseases are caused by a defect in mitochondrial function. ADCK3 protein has been shown to play a role in mitochondrial protein synthesis, and therefore it may have a potential role in treating mitochondrial diseases.

Can ADCK3 protein be used to diagnose CoQ10 deficiency?

ADCK3 protein levels may provide indirect information about CoQ10 levels in the body, but it is not a direct diagnostic tool for CoQ10 deficiency. Diagnosis of CoQ10 deficiency usually requires specific tests that measure CoQ10 levels in blood or tissues.