Recombinant Human ANAPC1, His-tagged
Cat.No. : | ANAPC1-9633H |
Product Overview : | Recombinant Human ANAPC1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | C-term-349a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | ANAPC1 anaphase promoting complex subunit 1 [ Homo sapiens ] |
Official Symbol : | ANAPC1 |
Synonyms : | ANAPC1; anaphase promoting complex subunit 1; anaphase-promoting complex subunit 1; APC1; MCPR; TSG24; cyclosome subunit 1; mitotic checkpoint regulator; testis-specific gene 24 protein; anaphase-promoting complex 1 (meiotic checkpoint regulator); |
Gene ID : | 64682 |
mRNA Refseq : | NM_022662 |
Protein Refseq : | NP_073153 |
MIM : | 608473 |
UniProt ID : | Q9H1A4 |
Chromosome Location : | 2q12.1 |
Pathway : | APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (15)
Ask a questionWhile mutations in the ANAPC1 gene have been linked to familial adenomatous polyposis (FAP), a genetic condition that predisposes individuals to the development of colorectal polyps, there are currently no other known disease-associated genetic variants of ANAPC1. More extensive research is needed to determine if ANAPC1 mutations or genetic variations are associated with other diseases.
As of now, there are no specific drugs or compounds that directly target ANAPC1. However, research is ongoing to identify small molecules or inhibitors that can modulate the activity of the APC/C complex, which could indirectly affect ANAPC1 function.
ANAPC1 interacts with various other proteins to form the APC/C complex. Some known interacting partners include ANAPC2, ANAPC3, ANAPC4, and ANAPC5, which are subunits of the complex. Additionally, ANAPC1 interacts with other regulatory proteins and co-factors involved in the control of APC/C activity.
ANAPC1 is widely expressed in various cell types and tissues throughout the body. Its presence is essential for normal cell cycle progression in all dividing cells.
ANAPC1, along with other subunits of the APC/C complex, targets specific proteins for degradation by attaching ubiquitin molecules to them. This ubiquitination process marks these proteins for destruction by the proteasome, leading to the orderly progression of the cell cycle.
ANAPC1 expression and activity can be regulated by factors such as phosphorylation, interaction with other proteins, or cell cycle checkpoints. The precise regulatory mechanisms of ANAPC1 are still being elucidated.
Apart from cancer, ANAPC1 has been implicated in other diseases as well. For example, mutations in ANAPC1 have been linked to familial adenomatous polyposis (FAP), an inherited disorder characterized by the development of numerous polyps in the colon. These mutations likely disrupt the normal function of the APC/C complex, leading to abnormal cell proliferation and polyp formation.
Yes, ANAPC1 is a highly conserved protein across various species, ranging from yeast to humans. The conservation of ANAPC1 highlights its importance in fundamental cell cycle processes that are essential for the development and survival of organisms.
ANAPC1 expression levels and activity are tightly regulated during the cell cycle. Its levels are generally low during the G1 phase but increase as cells progress through the S, G2, and M phases. ANAPC1 activity is regulated by post-translational modifications, such as phosphorylation and acetylation, which can affect its interaction with other subunits of the APC/C complex and its binding to specific substrates.
Given its role in the cell cycle regulation and its involvement in cancer, ANAPC1 has emerged as a potential target for therapeutic interventions. However, more research is needed to fully understand the implications and feasibility of targeting ANAPC1 for various diseases.
Mutations in ANAPC1 have been found in certain types of cancer, including colorectal and gastric cancer. These mutations can disrupt the normal function of the APC/C complex, leading to aberrant cell cycle regulation and promoting tumor growth.
Emerging evidence suggests that ANAPC1 may have a role in DNA repair mechanisms. It has been found to interact with proteins involved in DNA repair pathways, such as BRCA1 and RAD51, indicating a potential role in maintaining genomic stability. However, further studies are needed to fully understand the significance of ANAPC1 in DNA repair processes.
ANAPC1 primarily functions as a core component of the APC/C complex, which is responsible for cell cycle progression. However, recent studies have suggested that ANAPC1 may also have additional roles in transcriptional regulation and chromatin organization, indicating its involvement in other cellular processes beyond cell cycle regulation.
While the main function of ANAPC1 is cell cycle regulation, emerging research suggests that it may have additional roles in processes like DNA repair and maintenance of genomic stability. However, further investigation is needed to fully understand these potential non-cell cycle related functions of ANAPC1.
As ANAPC1 plays a crucial role in cell cycle regulation, targeting it therapeutically could potentially be beneficial for certain diseases, especially cancer. However, developing specific inhibitors or modulators that specifically target ANAPC1 or the APC/C complex is not straightforward and requires further research.
Customer Reviews (5)
Write a reviewThe protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.
As a researcher utilizing ANAPC1 protein in my trials, I can highlight its advantages and the valuable support provided by the manufacturer in facilitating my research.
The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.
By using ANAPC1 protein, I can explore the mechanisms underlying cell division, cell cycle control, and the molecular pathways associated with these processes.
One major advantage of ANAPC1 protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.
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