Recombinant Mouse ANAPC1 Protein

• Cat.No.: ANAPC1-1619M
• Product Overview: Recombinant Mouse ANAPC1 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Mouse
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Anapc1 anaphase promoting complex subunit 1 [ Mus musculus ]
• Official Symbol: ANAPC1
• Gene ID: 17222
• mRNA Refseq: NM_008569.2
• Protein Refseq: NP_032595.2
• UniProt ID: P53995

Reviews

10/21/2022

The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

10/05/2020

As a researcher utilizing ANAPC1 protein in my trials, I can highlight its advantages and the valuable support provided by the manufacturer in facilitating my research.

07/07/2020

The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

12/06/2016

By using ANAPC1 protein, I can explore the mechanisms underlying cell division, cell cycle control, and the molecular pathways associated with these processes.

11/12/2016

One major advantage of ANAPC1 protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.

Q&As

Are there any genetic variants of ANAPC1 associated with diseases?

While mutations in the ANAPC1 gene have been linked to familial adenomatous polyposis (FAP), a genetic condition that predisposes individuals to the development of colorectal polyps, there are currently no other known disease-associated genetic variants of ANAPC1. More extensive research is needed to determine if ANAPC1 mutations or genetic variations are associated with other diseases.

Are there any specific drugs or compounds that target ANAPC1?

As of now, there are no specific drugs or compounds that directly target ANAPC1. However, research is ongoing to identify small molecules or inhibitors that can modulate the activity of the APC/C complex, which could indirectly affect ANAPC1 function.

Are there any known interacting partners of ANAPC1?

ANAPC1 interacts with various other proteins to form the APC/C complex. Some known interacting partners include ANAPC2, ANAPC3, ANAPC4, and ANAPC5, which are subunits of the complex. Additionally, ANAPC1 interacts with other regulatory proteins and co-factors involved in the control of APC/C activity.

Is ANAPC1 protein expressed in all cell types?

ANAPC1 is widely expressed in various cell types and tissues throughout the body. Its presence is essential for normal cell cycle progression in all dividing cells.

How does ANAPC1 regulate the cell cycle?

ANAPC1, along with other subunits of the APC/C complex, targets specific proteins for degradation by attaching ubiquitin molecules to them. This ubiquitination process marks these proteins for destruction by the proteasome, leading to the orderly progression of the cell cycle.

Are there any known regulatory mechanisms that control ANAPC1 expression or activity?

ANAPC1 expression and activity can be regulated by factors such as phosphorylation, interaction with other proteins, or cell cycle checkpoints. The precise regulatory mechanisms of ANAPC1 are still being elucidated.

Are there any other diseases or conditions associated with ANAPC1?

Apart from cancer, ANAPC1 has been implicated in other diseases as well. For example, mutations in ANAPC1 have been linked to familial adenomatous polyposis (FAP), an inherited disorder characterized by the development of numerous polyps in the colon. These mutations likely disrupt the normal function of the APC/C complex, leading to abnormal cell proliferation and polyp formation.

Is ANAPC1 protein conserved across different species?

Yes, ANAPC1 is a highly conserved protein across various species, ranging from yeast to humans. The conservation of ANAPC1 highlights its importance in fundamental cell cycle processes that are essential for the development and survival of organisms.

How is ANAPC1 protein regulated during the cell cycle?

ANAPC1 expression levels and activity are tightly regulated during the cell cycle. Its levels are generally low during the G1 phase but increase as cells progress through the S, G2, and M phases. ANAPC1 activity is regulated by post-translational modifications, such as phosphorylation and acetylation, which can affect its interaction with other subunits of the APC/C complex and its binding to specific substrates.

Can ANAPC1 be targeted for therapeutic interventions?

Given its role in the cell cycle regulation and its involvement in cancer, ANAPC1 has emerged as a potential target for therapeutic interventions. However, more research is needed to fully understand the implications and feasibility of targeting ANAPC1 for various diseases.

Are there any known mutations in ANAPC1 associated with diseases?

Mutations in ANAPC1 have been found in certain types of cancer, including colorectal and gastric cancer. These mutations can disrupt the normal function of the APC/C complex, leading to aberrant cell cycle regulation and promoting tumor growth.

Does ANAPC1 play a role in DNA repair?

Emerging evidence suggests that ANAPC1 may have a role in DNA repair mechanisms. It has been found to interact with proteins involved in DNA repair pathways, such as BRCA1 and RAD51, indicating a potential role in maintaining genomic stability. However, further studies are needed to fully understand the significance of ANAPC1 in DNA repair processes.

Does ANAPC1 have any other cellular functions besides cell cycle regulation?

ANAPC1 primarily functions as a core component of the APC/C complex, which is responsible for cell cycle progression. However, recent studies have suggested that ANAPC1 may also have additional roles in transcriptional regulation and chromatin organization, indicating its involvement in other cellular processes beyond cell cycle regulation.

Does ANAPC1 have any non-cell cycle related functions?

While the main function of ANAPC1 is cell cycle regulation, emerging research suggests that it may have additional roles in processes like DNA repair and maintenance of genomic stability. However, further investigation is needed to fully understand these potential non-cell cycle related functions of ANAPC1.

Can ANAPC1 be targeted for therapeutic interventions?

As ANAPC1 plays a crucial role in cell cycle regulation, targeting it therapeutically could potentially be beneficial for certain diseases, especially cancer. However, developing specific inhibitors or modulators that specifically target ANAPC1 or the APC/C complex is not straightforward and requires further research.