Recombinant Human RSPO3 Protein, Fc/His-tagged
Cat.No. : | RSPO3-441H |
Product Overview : | Recombinant Human RSPO3 fused with Fc/His tag at C-terminal was expressed in HEK293 cells. |
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Description : | This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. |
Source : | HEK293 cells |
Species : | Human |
Tag : | Fc/His |
Form : | Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4 |
Molecular Mass : | 56.3kD |
AA Sequence : | QNASRGRRQRRMHPNVSQGCQGGCA TCSDYNGCLSCKPRLFFALERIGMK QIGVCLSSCPSGYYGTRYPDINKCT KCKADCDTCFNKNFCTKCKSGFYLH LGKCLDNCPEGLEANNHTMECVSIV HCEVSEWNPWSPCTKKGKTCGFKRG TETRVREIIQHPSAKGNLCPPTNET RKCTVDDIEGRMDEPKSCDKTHTCP PCPAPELLGGPSVFLFPPKPKDTLM ISRTPEVTCVVVDVSHEDPEVKFNW YVDGVEVHNAKTKPREEQYNSTYRV VSVLTVLHQDWLNGKEYKCKVSNKA LPAPIEKTISKAKGQPREPQVYTLP PSREEMTKNQVSLTCLVKGFYPSDI AVEWESNGQPENNYKTTPPVLDSDG SFFLYSKLTVDKSRWQQGNVFSCSV MHEALHNHYTQKSLSLSPGK HHHHHH |
Endotoxin : | Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
Purity : | >95% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | RSPO3 R-spondin 3 [ Homo sapiens ] |
Official Symbol : | RSPO3 |
Synonyms : | RSPO3; R-spondin 3; R spondin 3 homolog (Xenopus laevis) , thrombospondin, type I, domain containing 2 , THSD2; R-spondin-3; FLJ14440; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain containing 2; thrombospondin type-1 domain-containing protein 2; PWTSR; THSD2; CRISTIN1; |
Gene ID : | 84870 |
mRNA Refseq : | NM_032784 |
Protein Refseq : | NP_116173 |
MIM : | 610574 |
UniProt ID : | Q9BXY4 |
Products Types
◆ Recombinant Protein | ||
RSPO3-423H | Recombinant Human RSPO3 Protein, His-tagged | +Inquiry |
RSPO3-35H | Recombinant Human RSPO3 Protein | +Inquiry |
RSPO3-14554M | Active Recombinant Mouse RSPO3 Protein | +Inquiry |
RSPO3-1946H | Recombinant Human RSPO3 protein, His & T7-tagged | +Inquiry |
RSPO3-0654H | Active Recombinant Human RSPO3 protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
RSPO3-1906HCL | Recombinant Human RSPO3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGenetic mutations in RSPO3 can disrupt normal development and tissue regeneration.
Targeting RSPO3 could offer advances in regenerative medicine and cancer therapy by modulating Wnt signaling.
RSPO3 plays a significant role in maintaining stem cell populations and influencing their differentiation.
It stimulates tissue development and regeneration by activating Wnt pathways, essential for cellular proliferation.
RSPO3, a member of the R-spondin family, enhances Wnt signaling, crucial for cellular growth and differentiation.
Altered RSPO3 activity is linked to cancer development and progression, particularly in colorectal cancer.
RSPO3 interacts synergistically with Wnt pathway components, amplifying signal transduction.
Customer Reviews (3)
Write a reviewDependable partner, a vital research collaborator.
Consistency in quality, invaluable for our experiments.
Reliable data source, accelerates our research progress.
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