Recombinant Human SLC4A1 protein, His&Myc-tagged

• Cat.No.: SLC4A1-3501H
• Product Overview: Recombinant Human SLC4A1 protein(P02730)(1-403aa), fused to N-terminal His tag and C-terminal Myc tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His&Myc
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 50.3 kDa
• Protein length: 1-403aa
• AA Sequence: MEELQDDYEDMMEENLEQEEYEDPD IPESQMEEPAAHDTEATATDYHTTS HPGTHKVYVELQELVMDEKNQELRW MEAARWVQLEENLGENGAWGRPHLS HLTFWSLLELRRVFTKGTVLLDLQE TSLAGVANQLLDRFIFEDQIRPQDR EELLRALLLKHSHAGELEALGGVKP AVLTRSGDPSQPLLPQHSSLETQLF CEQGDGGTEGHSPSGILEKIPPDSE ATLVLVGRADFLEQPVLGFVRLQEA AELEAVELPVPIRFLFVLLGPEAPH IDYTQLGRAAATLMSERVFRIDAYM AQSRGELLHSLEGFLDCSLVLPPTD APSEQALLSLVPVQRELLRRRYQSS PAKPDSSFYKGLDLNGGPDDPLQQT GQLFGGLVRDIRRRYPYYLSDITDA FSP
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) [ Homo sapiens ]
• Official Symbol: SLC4A1
• Synonyms: SLC4A1; solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); AE1, DI, EPB3, Waldner blood group , WD; band 3 anion transport protein; CD233; FR; Froese blood group; RTA1A; SW; Swann blood group; WR; Wright blood group; anion exchanger 1; anion exchanger-1; Waldner blood group; anion exchange protein 1; erythroid anion exchange protein; erythrocyte membrane protein band 3; solute carrier family 4, anion exchanger, number 1; DI; WD; AE1; WD1; BND3; EPB3; EMPB3; MGC116750; MGC116753; MGC126619; MGC126623
• Gene ID: 6521
• mRNA Refseq: NM_000342
• Protein Refseq: NP_000333
• UniProt ID: P02730

Reviews

05/18/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

05/10/2021

Friendly customer service and detailed answers to all the questions I asked!

12/30/2020

The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.

Q&As

Where is SLC4A1 mainly expressed?

SLC4A1 is expressed on the erythrocyte membrane and the basement membrane surface of renal type A intercalary cells.

What are the effects of mutations in the SLC4A1?

The reduced amount of SLC4A1 protein following the SLC4A1 mutation makes the erythrocyte membrane less stable and prone to detachment, and the resulting reduction in surface area/volume changes the shape of the erythrocyte from a biconcave disc shape to a spherical shape.

What biological function does SLC4A1 have?

The main function of SLC4A1 is to carry out HCO3-/Cl- transmembrane transport.

What diseases has SLC4A1 been closely associated with the study of?

SLC4A1 has been closely associated with studies of diseases such as distal renal tubular acidosis and hereditary spherocytosis.