Recombinant Mouse Slc4a1 Protein, Myc/DDK-tagged

• Cat.No.: Slc4a1-5936M
• Product Overview: Purified recombinant protein of mouse full-length solute carrier family 4 (anion exchanger), member 1 (Slc4a1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 103.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Slc4a1 solute carrier family 4 (anion exchanger), member 1 [ Mus musculus (house mouse) ]
• Official Symbol: Slc4a1
• Synonyms: SLC4A1; solute carrier family 4 (anion exchanger), member 1; band 3 anion transport protein; AE 1; MEB3; anion exchanger 1; anion exchange protein 1; solute carrier family 4 member 1; erythrocyte membrane protein band 3; Ae1; CD233; Empb3; l11Jus51
• Gene ID: 20533
• mRNA Refseq: NM_011403
• Protein Refseq: NP_035533
• UniProt ID: P04919

Reviews

05/18/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

05/10/2021

Friendly customer service and detailed answers to all the questions I asked!

12/30/2020

The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.

Q&As

Where is SLC4A1 mainly expressed?

SLC4A1 is expressed on the erythrocyte membrane and the basement membrane surface of renal type A intercalary cells.

What are the effects of mutations in the SLC4A1?

The reduced amount of SLC4A1 protein following the SLC4A1 mutation makes the erythrocyte membrane less stable and prone to detachment, and the resulting reduction in surface area/volume changes the shape of the erythrocyte from a biconcave disc shape to a spherical shape.

What biological function does SLC4A1 have?

The main function of SLC4A1 is to carry out HCO3-/Cl- transmembrane transport.

What diseases has SLC4A1 been closely associated with the study of?

SLC4A1 has been closely associated with studies of diseases such as distal renal tubular acidosis and hereditary spherocytosis.