Recombinant Rat Slc4a1 Protein, His&GST-tagged

• Cat.No.: Slc4a1-403R
• Product Overview: Recombinant Rat Slc4a1 Protein (Ile558-Phe675) with N-His&GST tag was expressed in E. coli.

Specification

• Description: Enables actin binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including positive regulation of T cell proliferation; response to alkaline pH; and response to carbon dioxide. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of iron deficiency anemia; metabolic acidosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)).
• Source: E. coli
• Species: Rat
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 43.2 kDa
  Accurate Molecular Mass: 43 kDa
• Protein length: Ile558-Phe675
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Slc4a1 solute carrier family 4 member 1 (Diego blood group) [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Slc4a1
• Synonyms: Slc4a1; solute carrier family 4 member 1 (Diego blood group); band 3 anion transport protein; AE 1; Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3); anion exchange protein 1; anion exchanger 1; solute carrier family 4 (anion exchanger), member 1
• Gene ID: 24779
• mRNA Refseq: NM_012651
• Protein Refseq: NP_036783
• UniProt ID: P23562

Reviews

05/18/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

05/10/2021

Friendly customer service and detailed answers to all the questions I asked!

12/30/2020

The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.

Q&As

Where is SLC4A1 mainly expressed?

SLC4A1 is expressed on the erythrocyte membrane and the basement membrane surface of renal type A intercalary cells.

What are the effects of mutations in the SLC4A1?

The reduced amount of SLC4A1 protein following the SLC4A1 mutation makes the erythrocyte membrane less stable and prone to detachment, and the resulting reduction in surface area/volume changes the shape of the erythrocyte from a biconcave disc shape to a spherical shape.

What biological function does SLC4A1 have?

The main function of SLC4A1 is to carry out HCO3-/Cl- transmembrane transport.

What diseases has SLC4A1 been closely associated with the study of?

SLC4A1 has been closely associated with studies of diseases such as distal renal tubular acidosis and hereditary spherocytosis.