Recombinant Human SLC4A1 protein, His-tagged

• Cat.No.: SLC4A1-3717H
• Product Overview: Recombinant Human SLC4A1 protein(1-200 aa), fused to His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein length: 1-200 aa
• AA Sequence: MEELQDDYEDMMEENLEQEEYEDPD IPESQMEEPAAHDTEATATDYHTTS HPGTHKVYVELQELVMDEKNQELRW MEAARWVQLEENLGENGAWGRPHLS HLTFWSLLELRRVFTKGTVLLDLQE TSLAGVANQLLDRFIFEDQIRPQDR EELLRALLLKHSHAGELEALGGVKP AVLTRSGDPSQPLLPQHSSLETQLF
• Purity: 95%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) [ Homo sapiens ]
• Official Symbol: SLC4A1
• Synonyms: SLC4A1; solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); AE1, DI, EPB3, Waldner blood group , WD; band 3 anion transport protein; CD233; FR; Froese blood group; RTA1A; SW; Swann blood group; WR; Wright blood group; anion exchanger 1; anion exchanger-1; Waldner blood group; anion exchange protein 1; erythroid anion exchange protein; erythrocyte membrane protein band 3; solute carrier family 4, anion exchanger, number 1; DI; WD; AE1; WD1; BND3; EPB3; EMPB3; MGC116750; MGC116753; MGC126619; MGC126623
• Gene ID: 6521
• mRNA Refseq: NM_000342
• Protein Refseq: NP_000333
• UniProt ID: P02730

Reviews

05/18/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

05/10/2021

Friendly customer service and detailed answers to all the questions I asked!

12/30/2020

The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.

Q&As

Where is SLC4A1 mainly expressed?

SLC4A1 is expressed on the erythrocyte membrane and the basement membrane surface of renal type A intercalary cells.

What are the effects of mutations in the SLC4A1?

The reduced amount of SLC4A1 protein following the SLC4A1 mutation makes the erythrocyte membrane less stable and prone to detachment, and the resulting reduction in surface area/volume changes the shape of the erythrocyte from a biconcave disc shape to a spherical shape.

What biological function does SLC4A1 have?

The main function of SLC4A1 is to carry out HCO3-/Cl- transmembrane transport.

What diseases has SLC4A1 been closely associated with the study of?

SLC4A1 has been closely associated with studies of diseases such as distal renal tubular acidosis and hereditary spherocytosis.