Recombinant Human TDP1 Protein, His-tagged
Cat.No. : | TDP1-2755H |
Product Overview : | Recombinant Human TDP1 Protein (Met1-Gly151) with a N-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
- Download
Description : | The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). |
Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 20.4 kDa Accurate Molecular Mass: 25 kDa |
Protein length : | Met1-Gly151 |
Endotoxin : | <1.0 EU per 1µg (determined by the LAL method). |
Purity : | > 90% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in PBS or others. |
Gene Name : | TDP1 tyrosyl-DNA phosphodiesterase 1 [ Homo sapiens (human) ] |
Official Symbol : | TDP1 |
Synonyms : | TDP1; tyrosyl-DNA phosphodiesterase 1; FLJ11090; SCAN1; tyr-DNA phosphodiesterase 1; MGC104252; |
Gene ID : | 55775 |
mRNA Refseq : | NM_001008744 |
Protein Refseq : | NP_001008744 |
MIM : | 607198 |
UniProt ID : | Q9NUW8 |
Products Types
◆ Recombinant Protein | ||
Tdp1-270M | Recombinant Mouse Tdp1 Protein, MYC/DDK-tagged | +Inquiry |
TDP1-3325H | Recombinant Human TDP1 Protein, GST-tagged | +Inquiry |
TDP1-5657R | Recombinant Rat TDP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
TDP1-4476R | Recombinant Rhesus Macaque TDP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
TDP1-3326H | Recombinant Human TDP1 Protein, Flag-tagged | +Inquiry |
◆ Lysates | ||
TDP1-1155HCL | Recombinant Human TDP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (4)
Ask a questionInhibition of TDP1 expression induces apoptosis in gastric cancer cells.
TDP1 has been closely associated with the study of diseases such as gastric cancer and lung cancer.
Lung adenocarcinoma tissues expressed higher levels of TDP1 compared to paraneoplastic and normal tissues.
TDP1 is involved in DNA damage repair and plays a driving role in tumorigenesis and development.
Customer Reviews (3)
Write a reviewVery professional customer service, fully understanding the needs of the customer and giving professional advice.
The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.
Fast and timely shipment helped me to get satisfactory experimental results in short time.
Ask a Question for All TDP1 Products
Required fields are marked with *
My Review for All TDP1 Products
Required fields are marked with *
Inquiry Basket