Recombinant Mouse Acot1, His-tagged

• Cat.No.: Acot1-3137M
• Product Overview: Acyl-coenzyme A thioesterase 1 (Acot1)

Specification

• Source: E. Coli or Yeast
• Species: Mouse
• Tag: His
• Form: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Protein length: 419
• Purity: >90%
• Notes: Small volumes of Acot1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
• Storage Buffer: PBS pH 7.4, 50% glycerol
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: Acot1 acyl-CoA thioesterase 1 [ Mus musculus ]
• Official Symbol: Acot1
• Synonyms: ACOT1; acyl-CoA thioesterase 1; acyl-coenzyme A thioesterase 1; long chain acyl-CoA hydrolase; cytosolic acyl-CoA thioesterase 1; acyl-CoA thioesterase 1, cytosolic; long chain acyl-CoA thioester hydrolase; inducible cytosolic acyl-coenzyme A thioester hydrolase; ACH2; Cte1; CTE-1; CTE-I; D12Ucla1
• Gene ID: 26897
• mRNA Refseq: NM_012006
• Protein Refseq: NP_036136
• Pathway: Biosynthesis of unsaturated fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, conserved biosystem; Fatty acid elongation, organism-specific biosystem; Fatty acid elongation, conserved biosystem; Omega-3 and omega-6 unsatur
• Function: acyl-CoA hydrolase activity; acyl-CoA hydrolase activity; acyl-CoA hydrolase activity; carboxylesterase activity; hydrolase activity; palmitoyl-CoA hydrolase activity; thiolester hydrolase activity

Q&As

Are there any mutations in the ACOT1 gene associated with disease?

Several genetic mutations in the ACOT1 gene have been associated with metabolic disorders, including obesity and insulin resistance.

What is the subcellular localization of ACOT1 protein?

ACOT1 protein is localized in the cytoplasm of cells.

What is the role of ACOT1 in lipid metabolism?

ACOT1 plays a crucial role in lipid metabolism by hydrolyzing long-chain acyl-CoA thioesters, which are intermediates in the beta-oxidation of fatty acids, and releasing free fatty acids that can be utilized for energy production or other metabolic processes.

Is ACOT1 expressed in all tissues?

ACOT1 is expressed in a variety of tissues, including the liver, heart, skeletal muscle, and brain.

What is the physiological significance of ACOT1?

ACOT1 is important for energy metabolism and is involved in regulating lipid storage and utilization. It has also been implicated in the development of obesity, metabolic disorders and cancer.

Is ACOT1 a membrane-bound protein?

ACOT1 is a soluble protein that is not membrane-bound.