Recombinant Mouse Aldh18a1 Protein, Myc/DDK-tagged

• Cat.No.: Aldh18a1-1590M
• Product Overview: Purified recombinant protein of mouse full-length aldehyde dehydrogenase 18 family, member A1 (Aldh18a1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 87.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Aldh18a1 aldehyde dehydrogenase 18 family, member A1 [ Mus musculus (house mouse) ]
• Official Symbol: Aldh18a1
• Synonyms: ALDH18A1; aldehyde dehydrogenase 18 family, member A1; delta-1-pyrroline-5-carboxylate synthase; P5CS; glutamate gamma-semialdehyde synthetase; aldehyde dehydrogenase family 18 member A1; delta-1-pyrroline-5-carboxylate synthetase; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase); Pycs; AI429789; 2810433K04Rik; MGC32233
• Gene ID: 56454
• mRNA Refseq: NM_153554
• Protein Refseq: NP_705782
• UniProt ID: Q9Z110

Reviews

01/15/2022

Its speed in modulating signaling pathways allowed us to obtain results quickly, saving valuable time.

03/14/2017

The product's ability to accelerate research progress made it invaluable for time-critical projects.

10/02/2016

Time-sensitive assays were notably improved by the swift effects of the product.

Q&As

What is the primary function of ALDH18A1?

ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthetase, an enzyme involved in proline biosynthesis.

Is ALDH18A1 associated with amino acid metabolism?

Yes, ALDH18A1 is associated with amino acid metabolism, specifically in the synthesis of the amino acid proline.

How does ALDH18A1 contribute to cellular homeostasis?

ALDH18A1 contributes to cellular homeostasis by regulating the production of proline, an amino acid with various cellular functions.

Are there diseases associated with ALDH18A1 dysfunction?

Mutations in ALDH18A1 can lead to a rare genetic disorder called type I hyperprolinemia, characterized by elevated levels of proline in the blood.

In what cellular processes does ALDH18A1 play a role?

ALDH18A1 participates in the conversion of glutamate to pyrroline-5-carboxylate, a crucial step in proline biosynthesis.

Can ALDH18A1 be targeted for therapeutic interventions?

Therapeutic interventions targeting ALDH18A1 may be explored for conditions related to proline metabolism, but this would require careful consideration due to the essential role of proline in various cellular processes.

What is the subcellular location of ALDH18A1?

ALDH18A1 is typically located in the mitochondria, where it carries out the biosynthesis of proline.