RCHY1
-
Official Full Name
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
-
Overview
RING finger and CHY1 zinc finger domain-containing protein 1 (RCHY1) is a newly identified RING-H2-type protein-ubiquitin E3 ligase that is expressed as multiple isoforms generated through alternative splicing of mRNA transcripts. Notably, RCHY1 is a p53- -
Synonyms
RCHY1; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; ring finger and CHY zinc finger domain containing 1 , zinc finger protein 363 , ZNF363; RING finger and CHY zinc finger domain-containing protein 1; androgen recepto;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
RCHY1 involved in several pathways and played different roles in them. We selected most pathways RCHY1 participated on our site, such as p signaling pathway, Ubiquitin mediated proteolysis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCHY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
p signaling pathway | MDM4;TNFRSF10B;PIDD1;RCHY1;CYCSB;MDM2;EI24;RFWD2;GADD45AB |
Ubiquitin mediated proteolysis | PIAS4A;HUWE1;SKP2;UBA2;CDC23;UBE2B;UBE2H;AIRE;ANAPC13 |
Measles | HSPA8;cgr2b;TLR9;CCND1;EIF2AK2;DDX58;HSPA1B;SH2D1A;IFNA21 |
RCHY1 has several biochemical functions, for example, ligase activity, p53 binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCHY1 itself. We selected most functions RCHY1 had, and list some proteins which have the same functions with RCHY1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ligase activity | MIB2;TTLL9;BIRC2;MARCH3;RBCK1;DTX2;RNF149;RNF180;UBE2NA |
p53 binding | AXIN1;CDKN2AIP;SETD7;TRIM29;ZMAT3;TRP53;SMARCB1;BANP;RCHY1 |
protein binding | ZFYVE9;HSD17B12;CNTF;ZNF227;KRR1;RAPGEF4;HER11;OGFR;UVRAG |
protein homodimerization activity | TREX2;PFKM;NTRK1;ACTN1;HPS4;GABPB2;KCNH2;TERF1;CRYBB2 |
receptor binding | SRPX2;RSPO1;LRRC4B;GBA;PPY;GRIN2A;IZUMO1;FGF12A;RASA1 |
ubiquitin-protein transferase activity | FBXW2;FBXO2;ARIH1;PARK2;IRAK1;HECW2;SIAH1;TRAF6;TRIP12 |
zinc ion binding | TADA2B;MORC2B;CA15C;ZFP276;SIAH2;POLR3K;MUL1B;AGBL3;GCH2 |
RCHY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCHY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCHY1.
TP53; NLK; AIG1; MEOX2; 25796
- Q&As
- Reviews
Q&As (6)
Ask a questionRCHY1 acts as an independent target in early-stage node-negative oral squamous cell carcinoma and may provide patients with more accurate diagnostic and prognostic information.
The association between RCHY1 and ovarian and breast cancer is mainly manifested in its regulation of hormone receptor expression, migration and invasion.
RCHY1, as a Ubiquitin ligase, has been found as a driving factor in a variety of cancers such as liver, prostate, and kidney cancer.
RCHY1 is expressed in different types of cancer, and its high expression is associated with poor prognosis and high risk of metastasis.
For breast and ovarian cancer patients, the polymorphisms of RCHY1 are associated with the risk of tumor recurrence and can be used as a biomarker to predict recurrence.
RCHY1 is involved in regulating apoptosis signaling pathways by mediating the single ubiquitination pathway and promoting apoptosis of tumor cells.
Customer Reviews (3)
Write a reviewExperiments using RCHY1 were very reproducible and allowed me to evaluate the results more accurately.
Due to stability of RCHY1 was still very good under different experimental conditions, indicating that it has a wide range of applications and adaptability.
The band definition of RCHY1 in Western blot was very high, which improved the confidence of the experiment.
Ask a Question for All RCHY1 Products
Required fields are marked with *
My Review for All RCHY1 Products
Required fields are marked with *