Active Native Human Luteinizing Hormone (85% Purity)

• Cat.No.: LH-840H
• Product Overview: Active Native Human Luteinizing Hormone (85% Purity) is extracted from Human pituitary glands.

Specification

• Source: Human pituitary glands
• Species: Human
• Tag: N/A
• Form: 10mM PBS, pH 7.4
• Purity: About 85% by SDS-PAGE
• Storage: -20°C or lower, for long term storage.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Reviews

07/11/2021

Excellent performance in the EMSA experiment.

08/14/2020

Useful in experimental models of calcium deficiency in mice.

09/15/2019

Apply for yeast double hybrid experiment.

04/19/2018

Effectively promote cell proliferation and division.

12/11/2016

None cytotoxicity and is beneficial to promote cell growth.

Q&As

Can patients with osteoporosis receive LHRH antagonist therapy?

There can be loss of bone mineral density so men at risk of osteoporosis should be carefully monitored or treated with bisphosphonates.

Is the antagonistic reaction of LH inhibitors reversible?

Inhibitors ablation are reversible.

Can LH drive proliferation, differentiation, and survival of multiple cell types?

LH activates extracellular signal-regulated kinase (ERK) and protein kinase B (PKB/AKT) to drive cell proliferation, differentiation and survival in a variety of cell types.

Can the LH signaling pathway be blocked with protein kinase A (PKA) inhibitors?

Yes,you can.Activated LHCGR couples to Gαs G-proteins to initiate the adenylyl cyclase, cAMP and protein kinase A (PKA) signaling pathway.

By which receptor does LH act?

LH act through the luteinizing hormone choriogonadotropin receptor (LHCGR).

Why does hormone therapy produce resistance?

Mechanisms include increased sensitivity of hormone receptors, hormone receptor variants, pathway activation without exposure to hormones (constitutive activation) or upregulated downstream survival pathways.

Can postmenopausal women achieve estrogen suppression without ovarian radiation or surgical removal?

Using a GnRH (or LH-releasing hormone (LHRH)) agonist (GnRHa,LHRHa) such as goserelin or leuprorelin, usually as a monthly depot injection.

What are the advantages of hormone therapy for cancer?

Hormone therapy can be used to reduce the size of the primary cancer before radical surgery or radiotherapy, or to reduce the risk of recurrence.

Can I get calcium by increasing my LH level?

At high hormone and receptor levels, LHCGR couples to Gαq G-proteins to activate phospholipase C and inositol phosphate signaling to increase intracellular Ca2+.

Does LH have the same structure as other gonadotropins?

Like all other gonadotropin hormones, are heterodimers consisting of two monomeric glycoproteins that combine to make a functional protein.They share a common α-subunit, with structural and functional specificity conferred through differing β-subunits.