Recombinant Human Luteinizing Hormone

• Cat.No.: LH-43H
• Product Overview: Recombinant Human Luteinizing Hormone was produced from yeast.

Specification

• Description: Luteinizing hormone (LH) is an important hormone of the reproductive system, which has found application in diagnosis and therapeutic medicine. It plays a vital role in the development and functioning of the reproductive system. Determination of LH concentration is important for detection of dysfunction of the pituitary variance axis, diagnosis of reproductive disorders, monitoring of antifertility programmes and in therapeutic preparations.LH levels are normally low during childhood and, in women, high after menopause. As LH is secreted as pulses, it is necessary to follow its concentration over a sufficient period of time to get a proper information about its blood level.During the reproductive years typical levels are between 1-20 IU/L. Physiologic high LH levels are seen during the LH surge (v.s.); typically they last 48 hours.
• Source: Yeast
• Species: Human
• Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
• Molecular Mass: 14.4kDa
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >95 % as determined by SDS-PAGE
• Applications: Western blotting, ELISA
• Storage: Store it under sterile conditions at -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.Samples are stable for up to twelve months from date of receipt at -80℃.

Reviews

07/11/2021

Excellent performance in the EMSA experiment.

08/14/2020

Useful in experimental models of calcium deficiency in mice.

09/15/2019

Apply for yeast double hybrid experiment.

04/19/2018

Effectively promote cell proliferation and division.

12/11/2016

None cytotoxicity and is beneficial to promote cell growth.

Q&As

Can patients with osteoporosis receive LHRH antagonist therapy?

There can be loss of bone mineral density so men at risk of osteoporosis should be carefully monitored or treated with bisphosphonates.

Is the antagonistic reaction of LH inhibitors reversible?

Inhibitors ablation are reversible.

Can LH drive proliferation, differentiation, and survival of multiple cell types?

LH activates extracellular signal-regulated kinase (ERK) and protein kinase B (PKB/AKT) to drive cell proliferation, differentiation and survival in a variety of cell types.

Can the LH signaling pathway be blocked with protein kinase A (PKA) inhibitors?

Yes,you can.Activated LHCGR couples to Gαs G-proteins to initiate the adenylyl cyclase, cAMP and protein kinase A (PKA) signaling pathway.

By which receptor does LH act?

LH act through the luteinizing hormone choriogonadotropin receptor (LHCGR).

Why does hormone therapy produce resistance?

Mechanisms include increased sensitivity of hormone receptors, hormone receptor variants, pathway activation without exposure to hormones (constitutive activation) or upregulated downstream survival pathways.

Can postmenopausal women achieve estrogen suppression without ovarian radiation or surgical removal?

Using a GnRH (or LH-releasing hormone (LHRH)) agonist (GnRHa,LHRHa) such as goserelin or leuprorelin, usually as a monthly depot injection.

What are the advantages of hormone therapy for cancer?

Hormone therapy can be used to reduce the size of the primary cancer before radical surgery or radiotherapy, or to reduce the risk of recurrence.

Can I get calcium by increasing my LH level?

At high hormone and receptor levels, LHCGR couples to Gαq G-proteins to activate phospholipase C and inositol phosphate signaling to increase intracellular Ca2+.

Does LH have the same structure as other gonadotropins?

Like all other gonadotropin hormones, are heterodimers consisting of two monomeric glycoproteins that combine to make a functional protein.They share a common α-subunit, with structural and functional specificity conferred through differing β-subunits.