Recombinant Human ALDH1A3 Protein (2-512 aa), His-tagged

• Cat.No.: ALDH1A3-2118H
• Product Overview: Recombinant Human ALDH1A3 Protein (2-512 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Full Length of Mature Protein.

Specification

• Description: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 58.0 kDa
• Protein length: 2-512 aa
• AA Sequence: ATANGAVENGQPDRKPPALPRPIRN LEVKFTKIFINNEWHESKSGKKFAT CNPSTREQICEVEEGDKPDVDKAVE AAQVAFQRGSPWRRLDALSRGRLLH QLADLVERDRATLAALETMDTGKPF LHAFFIDLEGCIRTLRYFAGWADKI QGKTIPTDDNVVCFTRHEPIGVCGA ITPWNFPLLMLVWKLAPALCCGNTM VLKPAEQTPLTALYLGSLIKEAGFP PGVVNIVPGFGPTVGAAISSHPQIN KIAFTGSTEVGKLVKEAASRSNLKR VTLELGGKNPCIVCADADLDLAVEC AHQGVFFNQGQCCTAASRVFVEEQV YSEFVRRSVEYAKKRPVGDPFDVKT EQGPQIDQKQFDKILELIESGKKEG AKLECGGSAMEDKGLFIKPTVFSEV TDNMRIAKEEIFGPVQPILKFKSIE EVIKRANSTDYGLTAAVFTKNLDKA LKLASALESGTVWINCYNALYAQAP FGGFKMSGNGRELGEYALAEYTEVK TVTIKLGDKNP
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: ALDH1A3 aldehyde dehydrogenase 1 family, member A3 [ Homo sapiens ]
• Official Symbol: ALDH1A3
• Synonyms: ALDH1A3; ALDH6; RALDH3; RALDH-3; ALDH1A6
• Gene ID: 220
• mRNA Refseq: NM_000693
• Protein Refseq: NP_000684
• MIM: 600463
• UniProt ID: P47895

Reviews

04/27/2022

The combination of high-quality ALDH1A3 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

11/05/2020

The manufacturer's extensive experience and expertise in the field of ALDH1A3 protein research make them a trusted partner.

10/14/2016

The manufacturer's commitment to providing excellent technical support is highly valuable.

Q&As

How is ALDH1A3 protein clinically relevant?

ALDH1A3 has been implicated in cancer stem cell maintenance and differentiation, making it a potential target for cancer therapy.

Can ALDH1A3 be a potential therapeutic target beyond cancer?

ALDH1A3 has implications beyond cancer, and its role in retinoic acid metabolism suggests potential therapeutic applications in developmental disorders and other diseases.

How does ALDH1A3 contribute to the epithelial-mesenchymal transition (EMT) process?

ALDH1A3 is involved in the EMT process, a crucial step in cancer metastasis, highlighting its significance in tumor invasion and spread.

In which cancers is ALDH1A3 protein overexpressed?

ALDH1A3 overexpression has been observed in various cancers, including breast, lung, ovarian, and pancreatic cancers.

Are there any ongoing clinical trials targeting ALDH1A3?

Clinical trials are exploring the therapeutic potential of targeting ALDH1A3, evaluating the safety and efficacy of novel drugs in cancer patients.