Recombinant Mouse ADAMTS5 Protein (262-930 aa), His-tagged

• Cat.No.: ADAMTS5-2037M
• Product Overview: Recombinant Mouse ADAMTS5 Protein (262-930 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length of Mature Protein.

Specification

• Description: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 77.8 kDa
• Protein length: 262-930 aa
• AA Sequence: SISRARQVELLLVADSSMARMYGRG LQHYLLTLASIANRLYSHASIENHI RLAVVKVVVLTDKDTSLEVSKNAAT TLKNFCKWQHQHNQLGDDHEEHYDA AILFTREDLCGHHSCDTLGMADVGT ICSPERSCAVIEDDGLHAAFTVAHE IGHLLGLSHDDSKFCEENFGTTEDK RLMSSILTSIDASKPWSKCTSATIT EFLDDGHGNCLLDLPRKQILGPEEL PGQTYDATQQCNLTFGPEYSVCPGM DVCARLWCAVVRQGQMVCLTKKLPA VEGTPCGKGRVCLQGKCVDKTKKKY YSTSSHGNWGSWGPWGQCSRSCGGG VQFAYRHCNNPAPRNSGRYCTGKRA IYRSCSVTPCPPNGKSFRHEQCEAK NGYQSDAKGVKTFVEWVPKYAGVLP ADVCKLTCRAKGTGYYVVFSPKVTD GTECRPYSNSVCVRGRCVRTGCDGI IGSKLQYDKCGVCGGDNSSCTKIIG TFNKKSKGYTDVVRIPEGATHIKVR QFKAKDQTRFTAYLALKKKTGEYLI NGKYMISTSETIIDINGTVMNYSGW SHRDDFLHGMGYSATKEILIVQILA TDPTKALDVRYSFFVPKKTTQKVNS VISHGSNKVGPHSTQLQWVTGPWLA CSRTCDTGWHTRTVQCQDGNRKLAK GCLLSQRPSAFKQCLLKKC
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) [ Mus musculus ]
• Official Symbol: ADAMTS5
• Synonyms: ADAMTS5; ADMP-2; ADAMTS-5; ADAM-TS 5; implantin; aggrecanase-2; ASMP-2; ADAMTS1; ADAM-TS5; ADAMTS11; AI481094; 9530092O11Rik
• Gene ID: 23794
• mRNA Refseq: NM_011782
• Protein Refseq: NP_035912
• UniProt ID: Q9R001

Reviews

06/24/2020

The staff was very nice, communicated with me positively and solved a lot of technical problems.

06/19/2020

The ADAMTS5 proteins purchased from your company is suitable for ELISA.

06/17/2020

Fast and timely shipment helped me to get satisfactory experimental results in short time.

Q&As

Do you offer ADAMTS5 fused with other tags?

We can provide you with the most suitable labels according to your experimental needs.

ADAMTS5 is used in studies of which diseases?

ADAMTS5 is used in the study of oral squamous cell carcinoma, gastric cancer, and many other cancers.

How does ADAMTS5 relate to Aggrecan?

ADAMTS5 can cut Aggrecan.

What is the structure domain of ADAMTS5?

DAMTS5 is composed of a signal peptide, a pro-domain, a catalytic metalloproteinase domain, a disintegrin-like domain, and other C-terminal ancillary domains (a central thrombospondin type 1 sequence repeat (central TSR) motif, a cysteine-rich domain, a spacer region, and an additional TSR motif).

What biological processes is ADAMTS5 involved in?

ADAMTS5 is involved in the degradation of polyproteoglycans.