Recombinant Mouse Aldh8a1 Protein, Myc/DDK-tagged
Cat.No. : | Aldh8a1-1594M |
Product Overview : | Purified recombinant protein of mouse full-length aldehyde dehydrogenase 8 family, member A1 (Aldh8a1), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 53.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Aldh8a1 aldehyde dehydrogenase 8 family, member A1 [ Mus musculus (house mouse) ] |
Official Symbol : | Aldh8a1 |
Synonyms : | ALDH8A1; aldehyde dehydrogenase 8 family, member A1; aldehyde dehydrogenase family 8 member A1; retinal dehydrogenase 4; retinal dehydrogenase type 4; Raldh4 |
Gene ID : | 237320 |
mRNA Refseq : | NM_178713 |
Protein Refseq : | NP_848828 |
UniProt ID : | Q8BH00 |
Products Types
◆ Recombinant Protein | ||
ALDH8A1-460M | Recombinant Mouse ALDH8A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALDH8A1-1534M | Recombinant Mouse ALDH8A1 Protein | +Inquiry |
ALDH8A1-502H | Recombinant Human Aldehyde Dehydrogenase 8 Family, Member A1, GST-tagged | +Inquiry |
ALDH8A1-9565H | Recombinant Human ALDH8A1, His-tagged | +Inquiry |
ALDH8A1-453H | Recombinant Human ALDH8A1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ALDH8A1-8914HCL | Recombinant Human ALDH8A1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionAs of now, there are no specific therapies or treatments targeting the ALDH8A1 protein. The focus is primarily on managing and treating the developmental disorders or diseases associated with ALDH8A1 gene mutations, such as Antley-Bixler syndrome, through supportive and symptomatic care.
While Antley-Bixler syndrome is the most well-known disease associated with ALDH8A1 gene mutations, there is increasing evidence suggesting potential roles for ALDH8A1 in other diseases. For example, it has been implicated in some forms of cancer, including ovarian and gastric cancer. However, further research is necessary to fully understand its involvement in these conditions.
While the primary function of the ALDH8A1 protein is the conversion of retinaldehyde to retinoic acid, the full extent of its functions is still being investigated. Some studies suggest its involvement in the detoxification of certain aldehydes, but further research is needed to fully understand its roles.
The ALDH8A1 protein is expressed in various tissues and organs of the body. It is found in high levels in the liver, as well as in other tissues such as the brain, kidney, lung, and small intestine.
The regulation of ALDH8A1 expression and activity is not fully understood. However, it is known that its expression can be influenced by various factors, including hormones, vitamin A levels, and developmental signaling pathways. Further research is needed to elucidate the precise mechanisms of its regulation.
The specific protein-protein interactions involving ALDH8A1 are not well-characterized. However, as an enzyme involved in retinoic acid metabolism, it likely interacts with other proteins in the retinoid signaling pathway. Some studies suggest that ALDH8A1 may interact with cellular retinoic acid-binding proteins (CRABP) and retinoic acid receptor (RAR) proteins, but more research is needed to confirm and fully understand these interactions.
Some compounds have been identified as possible inhibitors or activators of ALDH8A1 activity. For example, it has been found that disulfiram, a drug used to treat alcoholism, can inhibit ALDH8A1 activity. However, the therapeutic potential of these compounds in relation to ALDH8A1 function is not yet fully understood.
Mutations or dysregulation in the ALDH8A1 gene and protein have been associated with certain developmental disorders and diseases. One example is Antley-Bixler syndrome, a rare genetic disorder characterized by craniosynostosis (premature fusion of the skull bones) and other skeletal and genital abnormalities. ALDH8A1 mutations have been found in individuals with this condition.
Customer Reviews (4)
Write a reviewResearchers utilizing the Aldh8a1 Protein can rely on its robust and reproducible performance in a variety of experimental settings.
This protein has proven to be of great utility in protein electron microscopy structure analysis.
broad applicability make it a valuable asset for a wide range of research endeavors.
The Aldh8a1 Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.
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