Recombinant Rat Slc5a2 Protein, His-tagged

• Cat.No.: Slc5a2-2078R
• Product Overview: Recombinant Rat Slc5a2 Protein (Thr546-Ala648) with N-His tag was expressed in E. coli.

Specification

• Description: Enables glucose:sodium symporter activity. Involved in glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Located in brush border membrane. Is integral component of membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2).
• Source: E. coli
• Species: Rat
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 11.3 kDa
• Protein length: Thr546-Ala648
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Slc5a2 solute carrier family 5 member 2 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Slc5a2
• Synonyms: Slc5a2; solute carrier family 5 member 2; Sglt2; sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; low affinity Na-dependent glucose transporter (SGLT2); low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose cotransporter), member 2
• Gene ID: 64522
• mRNA Refseq: NM_022590
• Protein Refseq: NP_072112
• UniProt ID: P53792

Reviews

05/04/2022

Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

03/18/2022

The SLC5A2 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

05/01/2016

the SLC5A2 protein's compatibility with various experimental techniques adds to its versatility.

Q&As

Is there any potential for SLC5A2-targeted therapy in other organ systems?

SLC5A2 inhibitors may have implications beyond diabetes, including potential cardiovascular and renal protective effects.

How does the function of the SLC5A2 protein affect glucose homeostasis?

The SLC5A2 protein plays a crucial role in maintaining normal blood glucose levels by reabsorbing filtered glucose from the urine back into the bloodstream.

Are there any diagnostic tests for assessing SLC5A2-related conditions?

Genetic testing for SLC5A2 mutations can help identify individuals with renal glycosuria or other related conditions.

How do pharmaceutical companies target the SLC5A2 protein for drug development?

Pharmaceutical companies are developing SGLT2 inhibitors, which can selectively block the activity of the SLC5A2 protein to reduce glucose reabsorption in the kidneys.

Can SLC5A2 mutations lead to any adverse effects?

In individuals with SLC5A2 mutations, the increased excretion of glucose in the urine may predispose them to urinary tract infections and dehydration.