Recombinant Human SLC5A2

• Cat.No.: SLC5A2-30972TH
• Product Overview: Recombinant fragment of Human SGLT2 with a N terminal proprietary tag: predicted molecular weight 31.13 kDa inclusive of tag.

Specification

• Description: This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria.
• Protein length: 50 amino acids
• Molecular Weight: 31.130kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: GLFDKYLGAATSLTVSEDPAVGNIS SFCYRPRPDSYHLLRHPVTGDLPWP
• Sequence Similarities: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Gene Information

• Gene Name: SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 [ Homo sapiens ]
• Official Symbol: SLC5A2
• Synonyms: SLC5A2; solute carrier family 5 (sodium/glucose cotransporter), member 2; SGLT2; sodium/glucose cotransporter 2
• Gene ID: 6524
• mRNA Refseq: NM_003041
• Protein Refseq: NP_003032
• MIM: 182381
• Uniprot ID: P31639
• Chromosome Location: 16p12-p11
• Pathway: Na+-dependent glucose transporters, organism-specific biosystem; SLC-mediated transmembrane transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem
• Function: low-affinity glucose:sodium symporter activity; symporter activity; transporter activity

Reviews

05/04/2022

Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

03/18/2022

The SLC5A2 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

05/01/2016

the SLC5A2 protein's compatibility with various experimental techniques adds to its versatility.

Q&As

Is there any potential for SLC5A2-targeted therapy in other organ systems?

SLC5A2 inhibitors may have implications beyond diabetes, including potential cardiovascular and renal protective effects.

How does the function of the SLC5A2 protein affect glucose homeostasis?

The SLC5A2 protein plays a crucial role in maintaining normal blood glucose levels by reabsorbing filtered glucose from the urine back into the bloodstream.

Are there any diagnostic tests for assessing SLC5A2-related conditions?

Genetic testing for SLC5A2 mutations can help identify individuals with renal glycosuria or other related conditions.

How do pharmaceutical companies target the SLC5A2 protein for drug development?

Pharmaceutical companies are developing SGLT2 inhibitors, which can selectively block the activity of the SLC5A2 protein to reduce glucose reabsorption in the kidneys.

Can SLC5A2 mutations lead to any adverse effects?

In individuals with SLC5A2 mutations, the increased excretion of glucose in the urine may predispose them to urinary tract infections and dehydration.