CNR1
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Official Full Name
Cnr1 cannabinoid receptor 1 (brain)
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Synonyms
CNR1; cannabinoid receptor 1 (brain); cannabinoid receptor 1; brain-type cannabinoid receptor; striatal cannabinoid receptor type 1 protein; CB1; CB-R; CB1R;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Felis catus (Cat) (Felis silvestris catus)
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mus musculus (Mouse)
- Pan troglodytes (Chimpanzee)
- Pelophylax esculentus (Edible frog) (Rana esculenta)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Taeniopygia guttata (Zebra finch) (Poephila guttata)
- Taricha granulosa (Roughskin newt)
- Xenopus laevis (African clawed frog)
- Zea mays (Maize)
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Flag
- His|T7
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CNR1 Related Gene Family
- CNR1 Related Research Area
CNR1 involved in several pathways and played different roles in them. We selected most pathways CNR1 participated on our site, such as BDNF signaling pathway, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CNR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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BDNF signaling pathway | EIF4E;KCNN2;EEF2;GNB2L1;CSNK2A1;EIF2S1;CDKL5;FRS2;FRS3 |
Class A/1 (Rhodopsin-like receptors) | DRD3;NMBA;NMU;NMUR1;RGS1;ADRA2A;GAL;FPR-RS3;SSTR4 |
G alpha (i) signalling events | HCAR1-2;TAS2R3;CXCL11.8;TAS2R16;SSTR5;SST;LPAR2A;CCR7;RGS19 |
GPCR downstream signaling | CGA;CNR1;UTS2;RGR;TAAR1;GRP;GCGB;ADCYAP1R1;SOUL4 |
GPCR ligand binding | CCR1;TRH;S1PR3;TAS2R7;CCL35.1;SSTR2;CD97;ADCYAP1R1;EDN3 |
GPCRs, Class A Rhodopsin-like | FFAR3;GPR37L1;GPR12;GPR32;GPR85;SSTR1;APLNR;GPR77;CCR9 |
N-cadherin signaling events | GAP43;CNR1 |
Neuroactive ligand-receptor interaction | MC4R;GABRB1;GRM8;VIPR2;ADRA1BB;KISS1R;GRIA1A;HTR2B;CYSLTR2 |
CNR1 has several biochemical functions, for example, cannabinoid receptor activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CNR1 itself. We selected most functions CNR1 had, and list some proteins which have the same functions with CNR1. You can find most of the proteins on our site.
Function | Related Protein |
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cannabinoid receptor activity | CNR1;GPR55;CNR2 |
drug binding | PPARA;PPARD;FOLR2;PNP;PDE2A;DHODH;NR1I2;ADH1;PYGL |
CNR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CNR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CNR1.
ADORA2A; win 55212-2
- Q&As
- Reviews
Q&As (6)
Ask a questionThe protein receptor agonists can bind to receptors, activate receptors, and promote their signal transduction, resulting in physiological effects. CNR1 receptor antagonists, on the other hand, can bind to the receptor and prevent endocannabinoids from binding to the receptor, thereby inhibiting its signal transduction.
There are many types of mutations in the CNR1 gene, including single nucleotide substitution, insertion, or deletion. These mutations may cause structural and functional changes in the CNR1 receptor, affecting its binding and signal transduction to endocannabinoids.
CNR1 receptors play an important role in neuronal connections and neural circuits. It is involved in the growth, differentiation, and synapse formation of neurons, as well as in the regulation of neural circuits and signal transduction.
CNR1 receptors have potential applications in drug development. Some studies have shown that CNR1 receptor agonists or antagonists can be used to treat neurological disorders such as pain, depression, and anxiety.
Polymorphisms in the CNR1 gene may cause differences in individual responses to medications. Some polymorphisms may increase an individual's sensitivity or tolerance to medications, which can affect the efficacy and safety of medications.
For example, some drugs, toxins, or stressors may affect the expression level of the CNR1 gene, thus affecting its function and signal transduction processes.
Customer Reviews (3)
Write a reviewDNA binding ability is strong, and it performs well in related experiments.
The immunogenicity is very weak, does not cause an immune response, and has a high safety profile.
CNR1 has a long shelf life and good stability, which is convenient for the continuity of subsequent experiments.
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