APLN
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Official Full Name
apelin
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Overview
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. -
Synonyms
APLN; apelin; apelin, AGTRL1 ligand; XNPEP2; AGTRL1 ligand; APEL; APEL_HUMAN; Apelin-13; APJ endogenous ligand;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|MBP
- His|S
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | AAPLN-505H | Recombinant Human AAPLN protein, GST-tagged | Wheat Germ | GST | ||
Human | APLN-3549H | Recombinant Human APLN, His-tagged, S tagged | E.coli | His/S | 77 | |
Human | APLN-8261H | Recombinant Human APLN protein, His-tagged | E.coli | His | Ser24~Phe77 (Accession # Q9ULZ1) | |
Human | APLN-685H | Recombinant Human APLN protein, GST-tagged | Wheat Germ | GST | ||
Human | APLN-8262H | Recombinant Human APLN protein, His & MBP-tagged | E.coli | His/MBP | Ser24~Phe77 | |
Human | APLN-8792HCL | Recombinant Human APLN 293 Cell Lysate | HEK293 | N/A | ||
Human | APLN-301470H | Recombinant Human APLN protein, GST-tagged | E.coli | GST | Asn38-Phe77 | |
Human | APLN-0102H | Recombinant Human APLN Protein (Ser24-Phe77), N-GST-tagged | E.coli | N-GST | Ser24-Phe77 | |
Human | APLN-1070HF | Recombinant Full Length Human APLN Protein, GST-tagged | In Vitro Cell Free System | GST | 122 amino acids | |
Human | APLN-1071HF | Recombinant Full Length Human APLN Protein, GST-tagged | In Vitro Cell Free System | GST | 77 amino acids | |
Mouse | Apln-8263M | Recombinant Mouse Apln protein, His & GST-tagged | E.coli | His/GST | Val23~Phe77 (Accession # Q9R0R4) | |
Rat | APLN-714R | Recombinant Rat APLN Protein | Mammalian Cell | His | ||
Rat | Apln-8264R | Recombinant Rat Apln protein, His & S-tagged | E.coli | His/S | Ala19~Phe77 (Accession # Q9R0R3) | |
Rat | APLN-370R | Recombinant Rat APLN Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | APLN-370R-B | Recombinant Rat APLN Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | APLN-357R | Recombinant Rhesus monkey APLN Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | APLN-186R | Recombinant Rhesus Macaque APLN Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | APLN-186R-B | Recombinant Rhesus Macaque APLN Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | APLN-7588Z | Recombinant Zebrafish APLN | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
APLN involved in several pathways and played different roles in them. We selected most pathways APLN participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with APLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Class A/1 (Rhodopsin-like receptors) | XK;PENK;S1PR3;OXGR1A.2;TAC2;CHRM2;ADORA3;OXER1;CHRM3 |
G alpha (i) signalling events | AGT;CXCR6;ANXA1B;RLN3;OXER1;GAL;GPR55;OPN1SW;CXCR7B |
GPCR downstream signaling | SSTR1;PROK2;PROKR1A;CRHR1;OPN1SW1;CCK;OPN4B;ADCYAP1B;PTH |
GPCR ligand binding | SETD6;CNR2;GPR55;CRHR2;GPR132B;GPR77;RGS1;CASR;GPR120 |
Peptide ligand-binding receptors | FPR-RS6;NMB;CXCL11.8;NMBB;SSTR4;GPR37L1;RLN3A;ACKR4;EDN2 |
Signal Transduction | GPR55;IFT172;CRHB;KLHL12;STARD8;GPR39;ARHGAP12B;PTHLHA;TAS2R3 |
Signaling by GPCR | RCA2.1;ARHGAP4A;RGS18;ADM2;ARHGEF3;EDNRAB;CCL19A.2;PROK1;PRKCHB |
APLN has several biochemical functions, for example, G-protein coupled receptor binding, apelin receptor binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLN itself. We selected most functions APLN had, and list some proteins which have the same functions with APLN. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
G-protein coupled receptor binding | ARHGEF12;PICK1;ADORA1;PSAP;HSPA1A;NPB;GNA15.4;PROK1;GNAI2 |
apelin receptor binding | |
hormone activity | C19orf80;ADM2;GPHB5;NMB;GCG;STC2A;GCGA;AMH;SST1.1 |
receptor binding | GCG;ICAM3;INHA;LYN;FZD1;PVRL2;CLCF1;LBP;PIPOX |
APLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLN here. Most of them are supplied by our site. Hope this information will be useful for your research of APLN.
MDFI
- Q&As
- Reviews
Q&As (10)
Ask a questionYes, genetic engineering techniques are often used to produce APLN s.
There may be interactions, and it is recommended to avoid concurrent use of other drugs during use, especially those that affect the cardiovascular system.
APLN promotes cardiovascular protection and anti-tumor effects by binding to APJ receptors.
APLN has potential applications in the treatment of cardiovascular diseases, tumors and metabolic diseases.
APLN can be administered intravenously or subcutaneously.
Dosage should be determined according to the specific situation, it is recommended to consult with a professional doctor.
In the development process, it usually goes through a series of animal experiments to verify its effectiveness and safety.
Common side effects include injection site pain, fever, nausea, etc., but most patients tolerate them well.
APLN can promote blood vessel dilation, inhibit inflammatory response, and facilitate the survival and repair of cardiomyocytes.
There are currently no large-scale clinical trials to confirm its use in cancer treatment, but preliminary research results are promising.
Customer Reviews (3)
Write a reviewWestern blot experiments using this protein can obtain clearly distinguishable bands, indicating that it has high clarity and legibility.
In the course of repeated experiments, the stability of this protein has remained consistent, which provides us with great convenience.
I appreciate the manufacturer's pursuit of product quality, and their product repeatability is very good, which makes me more confident in the experimental results.
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