Recombinant Full Length Human ALDH1A3 Protein, GST-tagged

• Cat.No.: ALDH1A3-1402HF
• Product Overview: Human ALDH1A3 full-length ORF (BAG35229.1, 1 a.a. - 512 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 82.72 kDa
• Protein Length: 512 amino acids
• AA Sequence: MATANGAVEN GQPDRKPPAL PRPIRNLEVK FTKIFINNEW HESKSGKKFA TCNPSTREQI CEVEEGDKPD VDKAVEAAQV AFQRGSPWRR LDALSRGRLL HQLADLVERD RATLAALETM DTGKPFLHAF FIDLEGCIRT LRYFAGWADK IQGKTIPTDD NVVCFTRHEP IGVCGAITPW NFPLLMLVWK LAPALCCGNT MVLKPAEQTP LTALYLGSLI KEAGFPPGVV NIVPGFGPTV GAAISSHPQI NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE CAHQGVFFNQ GQCCTAASRV FVEEQVYSEF VRRSVEYAKK RPVGDPFDVK TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGPAMEDKG LFIKPTVFSE VTDNMRIAKE EIFGPVQPIL KFKSIEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWINCYNA LYAQAPFGGF KMSGNGRELG EYALAEYTEV KTVTIKLGDK NP
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ALDH1A3 aldehyde dehydrogenase 1 family, member A3 [ Homo sapiens ]
• Official Symbol: ALDH1A3
• Synonyms: ALDH1A3; aldehyde dehydrogenase 1 family, member A3; ALDH6; aldehyde dehydrogenase family 1 member A3; RALDH3; retinaldehyde dehydrogenase 3; RALDH-3; aldehyde dehydrogenase 6; acetaldehyde dehydrogenase 6; ALDH1A6
• Gene ID: 220
• mRNA Refseq: NM_000693
• Protein Refseq: NP_000684
• MIM: 600463
• UniProt ID: P47895

Reviews

04/27/2022

The combination of high-quality ALDH1A3 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

11/05/2020

The manufacturer's extensive experience and expertise in the field of ALDH1A3 protein research make them a trusted partner.

10/14/2016

The manufacturer's commitment to providing excellent technical support is highly valuable.

Q&As

How is ALDH1A3 protein clinically relevant?

ALDH1A3 has been implicated in cancer stem cell maintenance and differentiation, making it a potential target for cancer therapy.

Can ALDH1A3 be a potential therapeutic target beyond cancer?

ALDH1A3 has implications beyond cancer, and its role in retinoic acid metabolism suggests potential therapeutic applications in developmental disorders and other diseases.

How does ALDH1A3 contribute to the epithelial-mesenchymal transition (EMT) process?

ALDH1A3 is involved in the EMT process, a crucial step in cancer metastasis, highlighting its significance in tumor invasion and spread.

In which cancers is ALDH1A3 protein overexpressed?

ALDH1A3 overexpression has been observed in various cancers, including breast, lung, ovarian, and pancreatic cancers.

Are there any ongoing clinical trials targeting ALDH1A3?

Clinical trials are exploring the therapeutic potential of targeting ALDH1A3, evaluating the safety and efficacy of novel drugs in cancer patients.