Recombinant Human SLC5A2 Protein (Ser335-Leu423), C-His tagged

• Cat.No.: SLC5A2-6306H
• Product Overview: Recombinant human SLC5A2 (Ser335-Leu423) fused with the C-terminal His tag was expressed in mammalian cells.

Specification

• Source: Mammalian cells
• Species: Human
• Tag: C-His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 10.79 kDa
• Protein Length: Ser335-Leu423
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 [ Homo sapiens (human) ]
• Official Symbol: SLC5A2
• Synonyms: SLC5A2; solute carrier family 5 (sodium/glucose cotransporter), member 2; SGLT2; sodium/glucose cotransporter 2; Na (+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2
• Gene ID: 6524
• mRNA Refseq: NM_003041
• Protein Refseq: NP_003032
• MIM: 182381
• UniProt ID: P31639

Reviews

05/04/2022

Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

03/18/2022

The SLC5A2 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

05/01/2016

the SLC5A2 protein's compatibility with various experimental techniques adds to its versatility.

Q&As

Is there any potential for SLC5A2-targeted therapy in other organ systems?

SLC5A2 inhibitors may have implications beyond diabetes, including potential cardiovascular and renal protective effects.

How does the function of the SLC5A2 protein affect glucose homeostasis?

The SLC5A2 protein plays a crucial role in maintaining normal blood glucose levels by reabsorbing filtered glucose from the urine back into the bloodstream.

Are there any diagnostic tests for assessing SLC5A2-related conditions?

Genetic testing for SLC5A2 mutations can help identify individuals with renal glycosuria or other related conditions.

How do pharmaceutical companies target the SLC5A2 protein for drug development?

Pharmaceutical companies are developing SGLT2 inhibitors, which can selectively block the activity of the SLC5A2 protein to reduce glucose reabsorption in the kidneys.

Can SLC5A2 mutations lead to any adverse effects?

In individuals with SLC5A2 mutations, the increased excretion of glucose in the urine may predispose them to urinary tract infections and dehydration.