Recombinant Human SLC5A2 Transmembrane protein, His-SUMO & Myc-tagged

• Cat.No.: SLC5A2-2396H
• Product Overview: Recombinant Human SLC5A2 protein(P31639)(1-102aa), fused to N-terminal His-SUMO tag and C-terminal Myc tag, was expressed in E. coli.

Specification

• Source: In vitro E. coli expression system
• Species: Human
• Tag: His-SUMO & Myc
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 30.5kDa
• Protein Length: 1-102aa
• AA Sequence: MEEHTEAGSAPEMGAQKALIDNPAD ILVIAAYFLLVIGVGLWSMCRTNRG TVGGYFLAGRSMVWWPVGASLFASN IGSGHFVGLAGTGAASGLAVAGFEW NA
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 [ Homo sapiens ]
• Official Symbol: SLC5A2
• Synonyms: SLC5A2; solute carrier family 5 (sodium/glucose cotransporter), member 2; SGLT2; sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2
• Gene ID: 6524
• mRNA Refseq: NM_003041
• Protein Refseq: NP_003032
• MIM: 182381
• UniProt ID: P31639

Reviews

05/04/2022

Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

03/18/2022

The SLC5A2 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

05/01/2016

the SLC5A2 protein's compatibility with various experimental techniques adds to its versatility.

Q&As

Is there any potential for SLC5A2-targeted therapy in other organ systems?

SLC5A2 inhibitors may have implications beyond diabetes, including potential cardiovascular and renal protective effects.

How does the function of the SLC5A2 protein affect glucose homeostasis?

The SLC5A2 protein plays a crucial role in maintaining normal blood glucose levels by reabsorbing filtered glucose from the urine back into the bloodstream.

Are there any diagnostic tests for assessing SLC5A2-related conditions?

Genetic testing for SLC5A2 mutations can help identify individuals with renal glycosuria or other related conditions.

How do pharmaceutical companies target the SLC5A2 protein for drug development?

Pharmaceutical companies are developing SGLT2 inhibitors, which can selectively block the activity of the SLC5A2 protein to reduce glucose reabsorption in the kidneys.

Can SLC5A2 mutations lead to any adverse effects?

In individuals with SLC5A2 mutations, the increased excretion of glucose in the urine may predispose them to urinary tract infections and dehydration.