Recombinant Mouse ALDH8A1 Protein Pre-coupled Magnetic Beads

• Cat.No.: ALDH8A1-460M-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Mouse
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Aldh8a1 aldehyde dehydrogenase 8 family, member A1 [ Mus musculus ]
• Official Symbol: ALDH8A1
• Gene ID: 237320
• mRNA Refseq: NM_178713.4
• Protein Refseq: NP_848828.1
• UniProt ID: Q8BH00

Reviews

10/26/2019

Researchers utilizing the Aldh8a1 Protein can rely on its robust and reproducible performance in a variety of experimental settings.

12/20/2018

This protein has proven to be of great utility in protein electron microscopy structure analysis.

04/09/2017

broad applicability make it a valuable asset for a wide range of research endeavors.

04/27/2016

The Aldh8a1 Protein comes highly recommended for its exceptional performance, particularly in ELISA assays.

Q&As

Are there any therapies or treatments specifically targeting the ALDH8A1 protein?

As of now, there are no specific therapies or treatments targeting the ALDH8A1 protein. The focus is primarily on managing and treating the developmental disorders or diseases associated with ALDH8A1 gene mutations, such as Antley-Bixler syndrome, through supportive and symptomatic care.

What are the potential roles of the ALDH8A1 protein in diseases other than Antley-Bixler syndrome?

While Antley-Bixler syndrome is the most well-known disease associated with ALDH8A1 gene mutations, there is increasing evidence suggesting potential roles for ALDH8A1 in other diseases. For example, it has been implicated in some forms of cancer, including ovarian and gastric cancer. However, further research is necessary to fully understand its involvement in these conditions.

Are there any other known functions or roles of the ALDH8A1 protein?

While the primary function of the ALDH8A1 protein is the conversion of retinaldehyde to retinoic acid, the full extent of its functions is still being investigated. Some studies suggest its involvement in the detoxification of certain aldehydes, but further research is needed to fully understand its roles.

Where is the ALDH8A1 protein expressed in the body?

The ALDH8A1 protein is expressed in various tissues and organs of the body. It is found in high levels in the liver, as well as in other tissues such as the brain, kidney, lung, and small intestine.

How is the ALDH8A1 protein regulated?

The regulation of ALDH8A1 expression and activity is not fully understood. However, it is known that its expression can be influenced by various factors, including hormones, vitamin A levels, and developmental signaling pathways. Further research is needed to elucidate the precise mechanisms of its regulation.

Are there any known interacting partners or proteins that interact with ALDH8A1?

The specific protein-protein interactions involving ALDH8A1 are not well-characterized. However, as an enzyme involved in retinoic acid metabolism, it likely interacts with other proteins in the retinoid signaling pathway. Some studies suggest that ALDH8A1 may interact with cellular retinoic acid-binding proteins (CRABP) and retinoic acid receptor (RAR) proteins, but more research is needed to confirm and fully understand these interactions.

Are there any inhibitors or activators of the ALDH8A1 protein?

Some compounds have been identified as possible inhibitors or activators of ALDH8A1 activity. For example, it has been found that disulfiram, a drug used to treat alcoholism, can inhibit ALDH8A1 activity. However, the therapeutic potential of these compounds in relation to ALDH8A1 function is not yet fully understood.

How is the ALDH8A1 protein related to human health?

Mutations or dysregulation in the ALDH8A1 gene and protein have been associated with certain developmental disorders and diseases. One example is Antley-Bixler syndrome, a rare genetic disorder characterized by craniosynostosis (premature fusion of the skull bones) and other skeletal and genital abnormalities. ALDH8A1 mutations have been found in individuals with this condition.