GP1BA
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Official Full Name
glycoprotein Ib (platelet), alpha polypeptide
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Overview
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. -
Synonyms
BSS; GP1B; CD42B; mgC34595; CD42b-alpha; GP1BA; platelet glycoprotein Ib alpha chain; GPIbA GP-Ib alpha antigen CD42b-alpha platelet membrane glycoprotein 1b-alpha subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Mus musculus (Mouse)
- E.coli
- E.coli expression system
- HEK293
- HEK293-EBNA1 cells
- HEK293F
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- GST
- Myc
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- GP1BA Related Articles
- GP1BA Related Research Area
GP1BA involved in several pathways and played different roles in them. We selected most pathways GP1BA participated on our site, such as ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP1BA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ECM-receptor interaction | TNR;SPP1;ITGB7;COL27A1;FN1;COL11A1A;ITGB3B;COL6A2;COL4A1 |
Platelet activation | PLA2G4A;MAPK12;MYLK4;PLCG2;PRKACA;AKT1;ITPR3;PIK3R2;PRKCZ |
Hematopoietic cell lineage | IL5;CD3E;GM13305;KIT;EPO;CD1A;MS4A1;GP1BB;GYPA |
GP1BA has several biochemical functions, for example, protein binding, thrombin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GP1BA itself. We selected most functions GP1BA had, and list some proteins which have the same functions with GP1BA. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | PPM1K;RCHY1;LAGE3;TFPT;DKK1B;MYH10;MYO7A;TMEM74;OOEP |
thrombin receptor activity | F2R;F2RL1;F2RL1.2;GP1BA;F2RL1.1;F2RL2 |
GP1BA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP1BA here. Most of them are supplied by our site. Hope this information will be useful for your research of GP1BA.
VWF; GP9; YWHAZ; F2; F12; GP1BB; FLNA; YWHAQ; YWHAB; YWHAG; YWHAE; YWHAH
- Q&As
- Reviews
Q&As (7)
Ask a questionGlycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.
Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.
GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.
Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.
GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.
GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.
There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.
Customer Reviews (3)
Write a reviewIts compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.
The product's support in the form of educational resources positively impacted the learning curve for our researchers.
The product's track record of being featured in influential publications positively influenced our decision to use it.
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