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GP1BA

  • Official Full Name

    glycoprotein Ib (platelet), alpha polypeptide

  • Overview

    Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
  • Synonyms

    BSS; GP1B; CD42B; mgC34595; CD42b-alpha; GP1BA; platelet glycoprotein Ib alpha chain; GPIbA GP-Ib alpha antigen CD42b-alpha platelet membrane glycoprotein 1b-alpha subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293-EBNA1 cells
  • HEK293F
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • Myc
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GP1BA-5130H Recombinant Human GP1BA Protein, GST-tagged Wheat Germ GST
Human GP1BA-1832H Recombinant Human GP1BA protein, His-tagged E.coli His Leu136~Pro276 (Accession # P07359)
Human GP1BA-17H Recombinant Human glycoprotein Ibα, His-tagged, double sulfated HEK293-EBNA1 cells His
Human GP1BA-18H Recombinant Human glycoprotein Ibα, His-tagged, fully sulfated HEK293-EBNA1 cells His
Human GP1BA-1511H Recombinant Human GP1BA protein, His & T7-tagged E.coli His/T7 Ile19~Leu291 (Accession # P07359)
Human GP1BA-21H Recombinant Human GP1BA, His-tagged, Single-sulfated HEK293-EBNA1 cells His
Human GP1BA-19H Recombinant Human glycoprotein Ibα, His-tagged, non-sulfated HEK293-EBNA1 cells His
Human GP1BA-5823HCL Recombinant Human GP1BA 293 Cell Lysate HEK293 N/A
Human GP1BA-16H Recombinant Human GP1BA Protein, His-tagged HEK293 His Met1-Gly519
Human GP1BA-1401H Recombinant Human GP1BA Protein (17-531 aa), His-tagged Yeast His 17-531 aa
Human GP1BA-531H Recombinant Human GP1BA Protein (17-505 aa), His-tagged E.coli His 17-505 aa
Human GP1BA-2983H Recombinant Human GP1BA protein, GST-tagged E.coli GST 17-531aa
Human GP1BA-683H Recombinant Human GP1BA Protein, His-tagged HEK293F N-His Ile19-Leu291
Human GP1BA-2984H Recombinant Human GP1BA protein, His&Myc-tagged E.coli His&Myc 553-652aa
Human GP1BA-5462HF Recombinant Full Length Human GP1BA Protein, GST-tagged In Vitro Cell Free System GST 626 amino acids
Human GP1BA-2341H Recombinant Human GP1BA Protein (Leu136-Pro276), His tagged E.coli His Leu136-Pro276
Human GP1BA-4205H Recombinant Human GP1BA Protein (Met1-Leu531), C-His tagged Mammalian cells C-His Met1-Leu531
Mouse Gp1ba-1512M Recombinant Mouse Gp1ba protein, His & T7-tagged E.coli His/T7 Gln17~Thr282 (Accession # O35930)
Mus musculus (Mouse) RFL28600MF Recombinant Full Length Mouse Platelet Glycoprotein Ib Alpha Chain(Gp1Ba) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (17-734)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GP1BA Related Articles
  • GP1BA Related Research Area

GP1BA involved in several pathways and played different roles in them. We selected most pathways GP1BA participated on our site, such as ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP1BA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionTNR;SPP1;ITGB7;COL27A1;FN1;COL11A1A;ITGB3B;COL6A2;COL4A1
Platelet activationPLA2G4A;MAPK12;MYLK4;PLCG2;PRKACA;AKT1;ITPR3;PIK3R2;PRKCZ
Hematopoietic cell lineageIL5;CD3E;GM13305;KIT;EPO;CD1A;MS4A1;GP1BB;GYPA

GP1BA has several biochemical functions, for example, protein binding, thrombin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GP1BA itself. We selected most functions GP1BA had, and list some proteins which have the same functions with GP1BA. You can find most of the proteins on our site.

Function Related Protein
protein bindingPPM1K;RCHY1;LAGE3;TFPT;DKK1B;MYH10;MYO7A;TMEM74;OOEP
thrombin receptor activityF2R;F2RL1;F2RL1.2;GP1BA;F2RL1.1;F2RL2

GP1BA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP1BA here. Most of them are supplied by our site. Hope this information will be useful for your research of GP1BA.

VWF; GP9; YWHAZ; F2; F12; GP1BB; FLNA; YWHAQ; YWHAB; YWHAG; YWHAE; YWHAH

Bragadottir, G; Birgisdottir, ER; et al. Clinical phenotype in heterozygote and biallelic Bernard-Soulier syndrome-A case control study. AMERICAN JOURNAL OF HEMATOLOGY 90:149-155(2015).
Biguzzi, E; Franchi, F; et al. Genetic background and risk of postpartum haemorrhage: results from an Italian cohort of 3219 women. HAEMOPHILIA 20:E377-E383(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary function of Glycoprotein Ib platelet subunit alpha (GP1BA) in platelet physiology and hemostasis? 05/05/2022

Glycoprotein Ib platelet subunit alpha (GP1BA) plays a crucial role in platelet physiology and hemostasis, specifically in platelet adhesion.

What diseases or conditions are associated with dysregulation or abnormal expression of GP1BA? 11/24/2021

Dysregulation or abnormal expression of GP1BA is associated with conditions such as Bernard-Soulier syndrome and other platelet disorders.

How does GP1BA contribute to platelet adhesion and the formation of platelet plugs at sites of vascular injury? 12/03/2020

GP1BA contributes to platelet adhesion by interacting with von Willebrand factor (vWF), facilitating platelet plug formation at vascular injury sites.

What are the interactions or binding partners of GP1BA, and how do they influence platelet function? 08/13/2020

Interactions or binding partners of GP1BA include vWF and other components of the platelet glycoprotein Ib-IX-V complex, influencing platelet function.

How does GP1BA participate in the regulation of blood clotting and coagulation cascades? 01/06/2019

GP1BA participates in the regulation of blood clotting and coagulation cascades by initiating platelet activation and aggregation.

In which cellular compartments is GP1BA predominantly localized, especially within platelets? 08/24/2018

GP1BA is predominantly localized on the surface of platelets, especially within the platelet membrane.

Are there therapeutic implications or potential targets related to GP1BA in diseases involving platelet disorders? 03/06/2018

There are potential therapeutic implications related to GP1BA in diseases involving platelet disorders, making it a target for drug development.

Customer Reviews (3)

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Reviews
11/04/2022

    Its compatibility with collaborative platforms and open-source tools facilitated sharing and reproducibility of our experiments.

    04/12/2022

      The product's support in the form of educational resources positively impacted the learning curve for our researchers.

      06/24/2016

        The product's track record of being featured in influential publications positively influenced our decision to use it.

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