SUMF1
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Official Full Name
sulfatase modifying factor 1
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Overview
This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. -
Synonyms
SUMF1; sulfatase modifying factor 1; sulfatase-modifying factor 1; FGE; UNQ3037; FGly-generating enzyme; C-alpha-formylglycine-generating enzyme 1; AAPA3037; MGC131853; MGC150436;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Human
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
SUMF1 involved in several pathways and played different roles in them. We selected most pathways SUMF1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUMF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | AP3M1;CTSO;GNS;ARSA;ACP5A;Abca2;AP4S1;AP3B1;GNSB |
SUMF1 has several biochemical functions, for example, metal ion binding, oxidoreductase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SUMF1 itself. We selected most functions SUMF1 had, and list some proteins which have the same functions with SUMF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ADAP2;CSRP1B;PPTC7A;DDR1;ECE1;ZNF526;ZDHHC13;TNNC1;DSG1C |
| oxidoreductase activity | GFOD1;TYRP1B;SCCPDHA;TM9SF1;PHF2;HEPHL1;GSTO1;CYP2AA1;JMJD1C |
| protein homodimerization activity | BOKB;DMRTC1C2;APOA1BP;EFR3A;FZD1;HMOX1;ZHX2;MUC13;MIXL1 |
SUMF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUMF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUMF1.
q8clf6_yerpe; cona_canen; Hsd17b10; Lamp1
- Q&As
- Reviews
Q&As (7)
Ask a questionSUMF1 plays a role in lysosomal function, with implications for lysosomal storage diseases.
SUMF1 influences bone growth and development, potentially affecting skeletal health and disorders.
SUMF1 aids in the degradation of glycosaminoglycans, crucial for the breakdown of these complex molecules.
SUMF1 contributes to cellular detoxification, aiding in the breakdown of potentially harmful substances.
Variations in SUMF1 activity can impact neurological development and function, influencing brain health and disease.
SUMF1 deficiency leads to multiple sulfatase deficiency, disrupting normal metabolism and causing various symptoms.
SUMF1 is essential for the activation of sulfatase enzymes, impacting their role in cellular metabolism.
Customer Reviews (3)
Write a reviewExpert protein engineering support, an invaluable resource for our project.
Consistent western blot results, a lab necessity for our research.
Great protein crystallization service, vital for our structural biology work.
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