DHODH
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Official Full Name
dihydroorotate dehydrogenase (quinone)
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Overview
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. -
Synonyms
DHODH; dihydroorotate dehydrogenase (quinone); dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1; URA1; POADS; DHOdehase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- In vitro E. coli expression system
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DHODH Related Articles
DHODH involved in several pathways and played different roles in them. We selected most pathways DHODH participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHODH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolic pathways | FLAD1;Cel;ATP5H;MGAT5;NDUFA5;FASN;SDHDA;DHRS4L2;CYP2C55 |
Metabolism | ACAD11;PIK3R6;CEPT1A;DPYS;CYP2AD2;AMDHD1;CPT2;APOBB.1;SULT2ST1 |
Metabolism of nucleotides | TM9SF1;PNP5B;ADK;ADA;AK7A;PROZA;DUT;PAICS;UPP2 |
Pyrimidine biosynthesis | DHODH;DUT |
Pyrimidine metabolism | POLR3GLB;UPP1;TYMP;POLR2B;POLR2J2;TWISTNB;NT5C;CMPK1;NUDT2 |
DHODH has several biochemical functions, for example, FMN binding, dihydroorotate dehydrogenase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHODH itself. We selected most functions DHODH had, and list some proteins which have the same functions with DHODH. You can find most of the proteins on our site.
Function | Related Protein |
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FMN binding | NOS3;NOS2A;CREG1;HAO1;NOS2B;NOS2;TYW1B;POR;CREG2 |
dihydroorotate dehydrogenase activity | |
drug binding | ABP1;CHRNB4;DRD1A;UGT1A7;DHODH;DAAM2;CHRNA7;PYGM;PDXK |
ubiquinone binding | SDHD;SDHDB;ETFDH;SDHDA;DHODH;SDHB |
DHODH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHODH here. Most of them are supplied by our site. Hope this information will be useful for your research of DHODH.
MT2A; TMED10
- Q&As
- Reviews
Q&As (7)
Ask a questionIt catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.
DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.
DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.
DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.
Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.
Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.
Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.
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