Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

DHODH

  • Official Full Name

    dihydroorotate dehydrogenase (quinone)

  • Overview

    The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.
  • Synonyms

    DHODH; dihydroorotate dehydrogenase (quinone); dihydroorotate dehydrogenase; dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1; URA1; POADS; DHOdehase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHODH-11971H Active Recombinant Human DHODH protein, His-tagged E. coli His Arg35~Asp392
Human DHODH-2486H Recombinant Human Dihydroorotate Dehydrogenase (quinone), His-tagged E.coli His 31-395aa
Human DHODH-2590H Recombinant Human DHODH Protein, GST-tagged Wheat Germ GST
Human DHODH-11969H Recombinant Human DHODH, His-tagged E.coli His 1-395a.a.
Human DHODH-4839H Recombinant Human DHODH, MYC/DDK-tagged HEK293 Myc/DDK
Human DHODH-6944HCL Recombinant Human DHODH 293 Cell Lysate HEK293 N/A
Human DHODH-2532HF Recombinant Full Length Human DHODH Protein, GST-tagged In Vitro Cell Free System GST 165 amino acids
Human DHODH-6058H Recombinant Human DHODH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DHODH-1961H Recombinant Human DHODH Protein (Thr31-Arg395), His tagged E.coli His Thr31-Arg395
Human DHODH-11970H Recombinant Human DHODH protein, GST-tagged E.coli GST 395aa
Human DHODH15503H Recombinant Human DHODH (30-395) Protein, His-tagged E.coli His
Human DHODH-01H Active Recombinant Human DHODH Protein, Met/His-tagged E. coli
Human DHODH-3177HFL Recombinant Full Length Human DHODH, Flag-tagged Mamanlian cells Flag
Mouse DHODH-4558M Recombinant Mouse DHODH Protein Mammalian Cell His
Mouse DHODH-2355M Recombinant Mouse DHODH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DHODH-2541M Recombinant Mouse DHODH Protein (31-395 aa), His-tagged E.coli His 31-395 aa
Mouse Dhodh-2546M Recombinant Mouse Dhodh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Dhodh-2368M Recombinant Mouse Dhodh Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 11-395aa
Mouse Dhodh-5850M Recombinant Mouse Dhodh protein, His-tagged Insect Cell His 31-395aa
Mouse DHODH-09M Recombinant Mouse DHODH Protein E.coli
Mouse DHODH-2355M-B Recombinant Mouse DHODH Protein Pre-coupled Magnetic Beads HEK293
Rat DHODH-1859R Recombinant Rat DHODH Protein Insect Cell
Rat DHODH-10R Recombinant Rat DHODH Protein E.coli
Rat Dhodh-902R Recombinant Rat Dhodh Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-395aa
Rat DHODH-1517R-B Recombinant Rat DHODH Protein Pre-coupled Magnetic Beads HEK293
Rat DHODH-1517R Recombinant Rat DHODH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Dhodh-5849R Recombinant Rat Dhodh protein, His-tagged Insect Cell His 31-395aa
Bos taurus (Bovine) RFL30566BF Recombinant Full Length Bovine Dihydroorotate Dehydrogenase (Quinone), Mitochondrial(Dhodh) Protein, His-Tagged E.coli expression system His Full Length (1-395)
Homo sapiens (Human) RFL23160HF Recombinant Full Length Human Dihydroorotate Dehydrogenase (Quinone), Mitochondrial(Dhodh) Protein, His-Tagged E.coli expression system His Full Length (1-395)
Mus musculus (Mouse) RFL9773MF Recombinant Full Length Mouse Protein Dihydroorotate Dehydrogenase (Quinone), Mitochondrial(Dhodh) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (11-395aa)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL28959PF Recombinant Full Length Pongo Abelii Dihydroorotate Dehydrogenase (Quinone), Mitochondrial(Dhodh) Protein, His-Tagged E.coli expression system His Full Length (1-395)
Rattus norvegicus (Rat) RFL17236RF Recombinant Full Length Rat Dihydroorotate Dehydrogenase (Quinone), Mitochondrial(Dhodh) Protein, His-Tagged E.coli expression system His Full Length (1-395)
Zebrafish DHODH-1899Z Recombinant Zebrafish DHODH Mammalian Cell His
Chicken DHODH-1283C Recombinant Chicken DHODH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DHODH Related Articles

DHODH involved in several pathways and played different roles in them. We selected most pathways DHODH participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHODH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysFLAD1;Cel;ATP5H;MGAT5;NDUFA5;FASN;SDHDA;DHRS4L2;CYP2C55
MetabolismACAD11;PIK3R6;CEPT1A;DPYS;CYP2AD2;AMDHD1;CPT2;APOBB.1;SULT2ST1
Metabolism of nucleotidesTM9SF1;PNP5B;ADK;ADA;AK7A;PROZA;DUT;PAICS;UPP2
Pyrimidine biosynthesisDHODH;DUT
Pyrimidine metabolismPOLR3GLB;UPP1;TYMP;POLR2B;POLR2J2;TWISTNB;NT5C;CMPK1;NUDT2

DHODH has several biochemical functions, for example, FMN binding, dihydroorotate dehydrogenase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHODH itself. We selected most functions DHODH had, and list some proteins which have the same functions with DHODH. You can find most of the proteins on our site.

Function Related Protein
FMN bindingNOS3;NOS2A;CREG1;HAO1;NOS2B;NOS2;TYW1B;POR;CREG2
dihydroorotate dehydrogenase activity
drug bindingABP1;CHRNB4;DRD1A;UGT1A7;DHODH;DAAM2;CHRNA7;PYGM;PDXK
ubiquinone bindingSDHD;SDHDB;ETFDH;SDHDA;DHODH;SDHB

DHODH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHODH here. Most of them are supplied by our site. Hope this information will be useful for your research of DHODH.

MT2A; TMED10

Schaefer, CM; Schafer, MKH; et al. Region-Specific Distribution of Dihydroorotate Dehydrogenase in the Rat Central Nervous System Points to Pyrimidine De Novo Synthesis in Neurons. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 29:476-481(2010).
Thomson, TA; Spinella-Jaegle, S; et al. In vitro and In vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 56:35-42(2002).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does DHODH contribute to pyrimidine biosynthesis? 08/28/2022

It catalyzes a key step in the pyrimidine biosynthesis pathway, converting dihydroorotate to orotate.

What is the primary role of DHODH in cellular metabolism? 10/23/2020

DHODH, dihydroorotate dehydrogenase, is crucial for the de novo synthesis of pyrimidines, essential for DNA and RNA synthesis.

How does DHODH interact with other enzymes in the pyrimidine biosynthesis pathway? 10/27/2018

DHODH collaborates with other enzymes in pyrimidine biosynthesis, playing a role in nucleotide metabolism.

What role does DHODH play in cell proliferation and growth? 05/07/2018

DHODH is important for cell proliferation, as pyrimidine synthesis is essential for DNA replication and cell growth.

How do genetic variations in DHODH affect its function in nucleotide synthesis? 12/29/2017

Genetic mutations in DHODH can disrupt nucleotide synthesis, affecting cellular replication and function.

What is the impact of altered DHODH activity on autoimmune diseases? 08/01/2017

Altered DHODH activity is linked with autoimmune conditions, as it affects lymphocyte proliferation and function.

What potential therapeutic applications arise from targeting DHODH in disease treatment? 07/17/2017

Targeting DHODH in therapies could be effective in treating autoimmune diseases and certain cancers by modulating pyrimidine synthesis.

Customer Reviews (3)

Write a review
Reviews
07/29/2020

    Saves time and effort. Highly recommended for research.

    11/03/2017

      Top-notch support for insights. Trusted for accurate data.

      05/05/2017

        Reliable data, essential for our protein research.

        Ask a Question for All DHODH Products

        Required fields are marked with *

        My Review for All DHODH Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends