Epigenetics Small Molecules


Brief Introduction


Epigenetics Small Molecules

In the field of epigenetics, changes in DNA methylation and histone post-translational modification patterns are the focus of research. Many proteins are involved in the process of DNA methylation and histone modification, some of which participate in binding modified DNA or histones, and others can catalyze or remove those specific chemical groups. These epigenetic proteins have become emerging drug development targets for many diseases. Current researches have produced a large number of small-molecule drug candidates targeting epigenetic key factors and chromatin remodeling factors, and have also promoted the study of epigenetic modulators in diseases.

Creative BioMart has a series of small-molecule epigenetic modulators (including activators, antagonists, and inhibitors), and these include targets to DNA methyltransferases (DNMTs), DNA demethylases, histone methyltransferases (HMTs), histone demethylases (HDMs), histone acetyltransferases (HATs), histone deacetylases (HDACs), histone phosphorylation-related enzymes and reader domain-containing proteins. Because epigenetic regulation plays an important role in the occurrence and development of diseases such as cancer, these small-molecule epigenetic modulators are important tools for researchers to perform epigenetic drug discovery projects.

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