At least three systems including DNA methylation, histone modification and non-coding RNA (ncRNA)-associated gene silencing are currently thought to initiate and sustain epigenetic changes. The types of proteins and enzymes involved in these processes is numerous.

Creative BioMart offers recombinant proteins and native proteins from a variety of sources to meet your epigenetic research needs. Our proteins and enzymes include, but are not limited to, DNA methylation proteins, RNA methylation proteins, chromatin remodeling factors, histones, and various histone modifying enzymes (i.e. writer enzymes, eraser enzymes), as well as reader domain-containing proteins. These high-quality proteins and enzymes can be used in antibody production, structural analysis, and biochemical assays related to epigenetic research (such as Western blotting or enzymatic activity analysis).

As an international leading supplier of epigenetic protein products, Creative BioMart not only provides a wide range of off-the-shelf epigenetic proteins and enzymes, but also can custom-produce according to your specific requirements. Moreover, for industrial customers, our protein expression and purification platform can meet the requirements of bulk protein production, GMP protein production, protein modification and engineering.

• The histone H2A, H2B, H3 and H4 form an octamer on which eukaryotic DNA is wound to form nucleosomes. The histone H1 binds to the linker DNA between the nucleosomes, bringing ...

  Histones

• Histones undergo many post-translational modifications, such as methylation and acetylation, to regulate epigenetic transcription and gene expression. In the process of po...

  Histone Modification Proteins

• DNA methylation is the most basic epigenetic modification. In eukaryotes, the most common methylation modification is 5-methylcytosine (5mC), which is generated by attaching...

  DNA Modification Proteins

• To date, more than 100 kinds of RNA modifications have been found in vivo, among which m6A (N6-methyladenosine) modification is the most prevalent epigenetic modification of RNA level in eukary...

  RNA Modification Proteins

• The chromatin remodeling factor is a significant component of epigenetic regulation. In eukaryotic cells, different chromatin remodeling factors are localized to specific nucleosomes at a parti...

  Chromatin Remodeling Proteins

• To meet the constantly increasing research demands of our customers, Creative BioMart is expanding our protein products. In addition to proteins and enzymes that directly or indirectly particip...

  Other Proteins

Advantages of Our Proteins & Enzymes:

Wide Coverage

1. More than 5,000 proteins/enzymes/protein complexes involved in epigenetic regulation in stock;
2. Native, synthetic and recombinant proteins, and recombinant proteins are produced from multiple expression systems (E. coli, yeast, baculovirus-insect, mammalian cells and plant expression systems…);
3. Multiple species (human, monkey, bovine, cow, chicken, mouse, rat, rabbit, zebrafish…);
4. Recombinant proteins with different tags (His, GST, Strep, Flag, Fc, HA, T7, MBP, Avi, SOMO…) on N-terminus or C-terminus;
5. Full-length or partial fragments with various mutations.

Cost-effective Quality Products

1. Most of the products with > 90% purity as determined by SDS-PAGE and/or HPLC;
2. Most of the products with < 0.1 EU/μg endotoxin level as determined by LAL assay;
3. Validated bio-activity using functional ELISA and/or other activity assays;
4. Creative BioMart saves your money with competitive prices and a custom one-stop solution.