At Creative BioMart, we have a large compound library that contains many high-purity and high-quality bioactive small molecules related to epigenetics. Our histone acetyltransferase (HAT) modulators and inhibitors include a variety of targets, such as the p300/CBP-associated factor (PCAF) histone acetyltransferase.

The acetylation of many lysine residues in the terminal region of H3 and H4 by HATs can reduce the affinity of the entire nucleosome to DNA, and histone acetylation can also promote or prevent the interaction between chromatin and transcriptional regulatory factors. According to the source and function, there are two main types of HAT, HAT-A and HAT-B, the former exists in the nucleus and participates in the regulation of gene expression, and the latter exists in the cytoplasm and involves in the acetylation of newly synthesized core histones. And they can be divided into several large families based on the structural characteristics of HATs, such as GNAT family (Gcn5-related N-acetyltransferase), MYST family (MOZ, Ybf2/Sas3, Sas2 and Tip60) and p300/CBP.

HAT complexes are involved in many important physiological processes, such as transcriptional activation, gene silencing, cell cycle regulation, DNA replication, DNA repair and chromatin assembly. These HAT modulators and inhibitors can be used in enzyme activity inhibition assays to study the effect of histone acetylation on transcriptional regulation. It has been shown that some epigenetic modulators and inhibitors specific to histone acetylation can inhibit HATs.

Our prompt service, fast-turn-around time, dedicated customer service and reliable methods make us a popular supplier. Choose the appropriate bioactive small molecules in our product list, or we can customize according to your exact requirements. Please do not hesitate to contact us.