Histone Methylation Proteins

Brief Introduction

Histone methylation, first discovered in 1964, is a relatively stable post-translational modification (PTM) type, which derived from the interaction between the protein side chain with S-adenosyl methionine (SAM). This epigenetic modification, catalyzed by histone methyltransferases (HMTs), can occur at various sites of histones, but mainly occurs at the N-terminal lysine and arginine residues of H3 and H4, and it can be controlled by multiple positive and negative regulatory proteins to activate or inhibit transcription. This PTM is a very important and widespread chromatin modification that regulates gene expression by affecting the precise integration of chromatin or signal transduction, thereby affecting a variety of physiological processes in cells. The methylation of histones is reversible, and a considerable number of HMTs and histone demethylases (HDMs) have been identified, which jointly participate in mediating the methylation and demethylation of histones.

Creative BioMart provides numerous high-quality HMTs, HDMs, and proteins/protein complexes directly or indirectly related to histone methylation.

Online Inquiry

For Research Use Only. Not for use in diagnostic or therapeutic procedures.


Enter your email here to subscribe.

Follow us on

Easy access to products and services you need from our library via powerful searching tools

Copyright © Creative BioMart. All Rights Reserved.