Creative BioMart gladly supplies a variety of epigenetic modulators and inhibitors of premier grade to clients. We persist in being the most reliable vender of epigenetic products and services in the global market. We currently have the ability to provide you with various modulators and inhibitors of histone deacetylase (HDAC).

HDAC plays a role as part of the gene silencing process when the transcription of a gene is no longer needed, thus reducing the acetylation of nucleosomes and restoring chromatin into a transcriptionally inactive state. According to the homology with histones in yeast, the HDAC family in human can be divided into three types: 1) HDAC1, HDAC2, HDAC3 and HDAC8, which are only found in the nucleus; 2) HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10 and HDAC11, which shuttle between the nucleus and cytoplasm during signal transduction; 3) The last type is very different from the former two, and its activity is not dependent on Zn²⁺, but depends on Coenzyme A (NAD). It is homologous to yeast Sir2 and has at least 7 subtypes, and it cannot be inhibited by type I and II HDAC inhibitors (HDACIs).

HDACIs play a vital role in promoting epigenetics studies in cell cycle regulation, cell proliferation and cancer development by regulating the acetylation and deacetylation of lysine residues at the N-terminal of histone. And HDACI has become one of the hotspots in the research of anti-cancer drugs. The HDAC modulators and inhibitors provided by Creative BioMart are suitable for enzyme activity inhibition assays to study the effect of removal of acetyl groups on gene expression regulation. If you cannot find ideal bioactive small molecules in our product list or have any questions about our products, please do not hesitate to contact us, our team of scientists will provide you with a satisfactory solution.