| Cat.No.: | PE-1841 |
| Product Name: | CBX1 (human recombinant) |
| Description: | The heterochromatin protein 1 (HP1) family, which consists of three isoforms HP1α (CBX5), HP1β (CBX1), and HP1γ (CBX3) are chromatin-associated proteins involved in gene regulation and heterochromatin formation. CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain (CSD), and a hinge domain which connects the two. Extensive post-translational modifications have been observed and mapped on the CBX proteins. The chromodomain of CBX1 has been shown to recognize di- and tri-methylated lysine 9 on histone H3 (H3K9me2 and H3K9me3), with a preference for H3K9me3. Binding of CBX1 to methylated histones leads to gene silencing and heterochromatin formation. The CSD region of CBX1 is responsible for homodimerization and interaction with a number of non-histone chromatin-associated proteins, including the BRCA2-interacting protein EMSY, which may be involved in the development of breast and ovarian cancer. CBX1 also helps to reorganize chromatin as part of the DNA damage response systems by binding to sites of DNA damage through the CSD region. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 48.9 kDa |
| Purity: | ≥95% |
| Species: | human |
| Formulation: | 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Accession#: | P83916 |
| Alternative Names: | Chromobox Protein Homolog 1;Heterochromatin Protein 1 Homolog β;Heterochromatin Protein p25;HP1-β;HP1Hs-β;M31;Modifier 1 Protein;p25β |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0051 | Human CBX1 Knockout Cell Line 32bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0082 | HP1α, β and γ Polyclonal Antibody | Inquiry |
| EAb-0083 | HP1α Polyclonal Antibody | Inquiry |
| EAb-0149 | CBX1 Polyclonal Antibody | Inquiry |
| EAb-0677 | CBX1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| HP1 | HP1BP3 | ||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
