| Cat.No.: | PE-1847 |
| Product Name: | SP140 PHD and bromodomain (human recombinant) |
| Description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. Plant Homeodomain (PHD) fingers are zinc binding domains comprised of ~ 50 amino acids and have a Cys4-His-Cys3 motif. PHD fingers are found in more than 100 nuclear proteins that play a role in regulating chromatin. The C-terminal PHD and bromodomain regions of SP140 work in concert to bind to chromatin and ultimately regulate gene transcription. Nuclear bodies, which are involved in the pathogenesis of acute promyelocytic leukemia and viral infection, consist of several components, such as Sp100, NDP52, PML, and SP140. SP140 may play a role in the pathway that inactivates HIV-1 lacking viral infectivity factor (VIF). |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 49.2 kDa |
| Purity: | ≥95% |
| Species: | human |
| Formulation: | 50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerol |
| Alternative Names: | LYSp100;Speckled 140 kDa;SP140 Nuclear Body Protein |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0089 | Recombinant Human SP2 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0161 | Human SP1 Knockout Cell Line 2bp deletion | Inquiry |
| CL-0169 | Human SP140L Knockout Cell Line | Inquiry |
| CL-0170 | Human SP100 Knockout Cell Line 20bp deletion | Inquiry |
| CL-0171 | Human SP110 Knockout Cell Line 7bp deletion | Inquiry |
| Related Gene / Proteins | |||
| SP1 | SP100 | SP110 | SP140 |
| SP140L | SP2 | SP3 | SP6 |
| SPDL1 | SPF30 | SPIN1 | SPOP |
| SPT16 | SPT3 | Spt6 | SPTY2D1 |
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