| Cat.No.: | PE-1859 |
| Product Name: | PRMT6 (human recombinant; baculovirus expressed) |
| Description: | Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of ω-NG-monomethylarginine and asymmetric ω-NG,NG-dimethylarginine on both histone and non-histone targets. Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6. H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed Lineage Leukemia complex methyltransferase. Non-histone targets of PRMT6 include the nuclear high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 43.7 kDa |
| Purity: | ≥60% |
| Species: | human |
| Formulation: | 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride, and 20% glycerol |
| Accession#: | Q96LA8 |
| Alternative Names: | Histone Arginine N-methyltransferase PRMT6;HRMT1L6;Protein Arginine Methyltransferase 6 |
| Tag: | His |
| Expression System: | Sf21 Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| BSM-0047 | SGC707 | Inquiry |
| ◆ Antibodies | ||
| EAb-0048 | PRMT6 Polyclonal Antibody | Inquiry |
| EAb-0049 | PRMT7 Polyclonal Antibody | Inquiry |
| EAb-0050 | PRMT1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Pr-SET7 | PRC1 | PRC2 | PRDM1 |
| PRDM10 | PRDM11 | PRDM12 | PRDM13 |
| PRDM14 | PRDM15 | PRDM16 | PRDM17 |
| PRDM2 | PRDM3 | PRDM4 | PRDM5 |
| PRDM6 | PRDM7 | PRDM8 | PRDM9 More > |
| PREP1 | PRIM2 | PRKAA2 | PRKCA |
| PRKCB | PRKCE | PRKDC | PRKRIP1 |
| PRMT | prmt1 | PRMT2 | PRMT3 |
| PRMT5 | prmt6 | PRMT7 | PRMT8 |
| PRMT9 | Progerin | Protamine 2 | Prox1 |
| PRPF31 | PRPF40A | PRSS12 | PRSS55 |
| PRTFDC1 | |||
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