| Cat.No.: | PE-1868 |
| Product Name: | JMJD2E Strep-tagged (human recombinant) |
| Description: | Methylation of lysine residues in core histones plays a critical role in regulating gene expression. Jumonji domain containing 2E (JMJD2E) catalyzes the demethylation of histone H3 at lysince residue 9. Like other JmjC protein hydroxylase family members, JMJD2E is an α-ketoglutarate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 40.8 kDa |
| Purity: | ≥75% (by SDS-PAGE) |
| Species: | human |
| Formulation: | 20 mM HEPES, pH 7.4, and 150 mM sodium chloride |
| Accession#: | B2RXH2 |
| Alternative Names: | Jumonji Domain Containing 2E;KDM4D-Like |
| Tag: | Strep II |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| EAb-0075 | JMJD2b Polyclonal Antibody | Inquiry |
| EAb-0076 | JMJD2A Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | |
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