JMJD2A (human recombinant)

Cat.No.:	PE-1907
Product Name:	JMJD2A (human recombinant)
Description:	Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression. Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase. It catalyzes the demethylation of trimethylated histone at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an α-ketoglutarate-dependent Fe (II) oxygenase. JMJD2A’s transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	43 kDa
Purity:	≥95% (by SDS-PAGE)
Species:	human
Formulation:	A solution in 50 mM Hepes, pH 7.4, containing 150 mM sodium chloride and 20% glycerol
Accession#:	O75164
Alternative Names:	JHDM3A;Jumonji Domain Containing 2A;KDM4A
Tag:	His
Expression System:	E. coli
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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