| Cat.No.: | PE-2020 |
| Product Name: | SMYD2 Protein, Human, Recombinant (His Tag) |
| Product Overview: | Full length of human SMYD2 (NP_064582.2) (Met 1-His 433) with a polyhistidine tag at the N-terminus. |
| Background: | SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cells differentiation. SMYD2 mRNA is most highly expressed in heart and brain tissue. Over-expressed SMYD2 localizes to the cytoplasm and the nucleus in 293T cells. SMYD2 appears to restrain cell proliferation, likely through direct modulation of chromatin structure. Patients with SMYD2-overexpressing tumors had a worse overall rate of survival than those with non-expressing tumors, and SMYD2 positivity was independently associated with a worse outcome in the multivariate analysis. SMYD2 plays an important role in tumor cell proliferation through its activation/overexpression and regards as a prognosticator and potential therapeutic target in esophageal squamous cell carcinoma (ESCC). |
| Applications: | ELISA; Western Blot , Enzyme activity assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | The recombinant human SMYD2 consists of 451 amino acids and predicts a molecular mass of 52 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions. |
| Purity: | > 97 % as determined by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilized from sterile 50mM Tris, 100mM NaCl, 10% glycedrol, pH 8.01. |
| Accession#: | NP_064582.2 |
| Alternative Names: | HSKM-B Protein, Human; KMT3C Protein, Human; ZMYND14 Protein, Human |
| Tag: | His |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method |
| Expression System: | Baculovirus-Insect Cells |
| Common Name: | SET and MYND domain containing 2 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0080 | AZ-505 ditrifluoroacetate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0120 | BRG1 bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 More > |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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