| Cat.No.: | PE-2206 |
| Product Name: | Recombinant Human CoREST protein |
| Background: | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. |
| Applications: | SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 20 kDa including tags |
| Purity: | >80 % SDS-PAGE. |
| Species: | Human |
| Formulation: | pH: 8.5; Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.05% DTT, 20% Glycerol |
| Accession#: | Q9UKL0 |
| Alternative Names: | COREST/KIAA0071/Nr2b2 |
| Tag: | His |
| Amino Acid Sequence: | RAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQ TNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQA ISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKP VKSPDNSIKMPEEEDEAPVLDVRYASAS |
| Sequence Similarities: | Belongs to the CoREST family.Contains 1 ELM2 domain.Contains 2 SANT domains. |
| Expression System: | E. coli |
| Post Translational Modifications: | Phosphorylated by HSV-1 protein kinases in case of infection. |
| Protein Length: | Protein fragment; 305 to 482 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0033 | Human COMMD3-BMI1 Knockout Cell Line | Inquiry |
| CL-0262 | Human COPS6 Knockout Cell Line 40bp deletion | Inquiry |
| CL-0271 | Human COPS7A Knockout Cell Line 2bp deletion | Inquiry |
| CL-0278 | Human COPS7B Knockout Cell Line 26bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0212 | Recombinant Human C17orf79 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| COMMD2 | COMMD3 | COMMD4 | COMMD6 |
| COMMD9 | COMT | COP1 | COPRS |
| COPS6 | COPS7A | COPS7B | CoREST |
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