Recombinant Human SIRT7 protein


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Cat.No.:  PE-2212
Product Name:  Recombinant Human SIRT7 protein
Background:  NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
Applications:  SDS-PAGE; Functional Studies
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Appearance:  Liquid
Species:  Human
Formulation:  pH: 8.00; Constituents: 0.395% Tris HCl, 0.05% Tween, 20% Glycerol, 0.58% Sodium chloride
Alternative Names:  NAD dependent deacetylase sirtuin 7/NAD dependent protein deacetylase sirtuin 7/NAD-dependent protein deacetylase sirtuin-7
Sequence Similarities:  Belongs to the sirtuin family. Class IV subfamily.Contains 1 deacetylase sirtuin-type domain.
Expression System:  E. coli
Post Translational Modifications:  Phosphorylated during mitosis.
Protein Length:  Full length protein
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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