| Cat.No.: | PE-2307 |
| Product Name: | Recombinant Human KAT3A / CBP protein |
| Background: | Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. |
| Applications: | SDS-PAGE; Western blot |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 51 kDa |
| Purity: | > 90 % SDS-PAGE. |
| Species: | Human |
| Formulation: | pH: 7.50; Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride |
| Accession#: | Q92793 |
| Alternative Names: | CBP/CBP_HUMAN/CREB binding protein |
| Amino Acid Sequence: | MRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGS NSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPT PDPAALKDR RMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQK ELEEKRRSRLHKQGILGNQ PALPAPGAQPPVIPQAQPVRPPNGPLSLP VNRMQVSQGMNSFNPMSLGNVQLPQAPMG PRAASPMNHSVQMNSMGSV PGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQ FPSSSGAMS VGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPT PPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGS VPSATQTQS TPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVH AQPPGTPLSQAAASIDNRV PTPSSVASAETNSQQPGPDVPVLEMKTET QAEDTEPDPGESKGEPRSEMMEEDLQGAS QVKEETDIAEQKSEPMEVD EKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPE ELRQALMPT LEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQ YQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQS LGYCCGRKY EFS |
| Sequence Similarities: | Contains 1 bromo domain.Contains 1 KIX domain.Contains 2 TAZ-type zinc fingers.Contains 1 ZZ-type zinc finger. |
| Expression System: | Sf9 Insect Cells |
| Post Translational Modifications: | Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response.Phosphorylated upon DNA damage, probably by ATM or ATR.Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX. |
| Protein Length: | Protein fragment; 518 to 1207 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0094 | C646 | Inquiry |
| BSM-0124 | EML-425 | Inquiry |
| BSM-0150 | I-CBP112 (Hydrochloride) | Inquiry |
| ◆ Research Kits | ||
| EKIT-0122 | CBP bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | ||
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