| Cat.No.: | PE-3004 |
| Product Name: | EZH2 Complex |
| Description: | A five-member complex (EZH2, AEBP2, EED, RbAp48, SUZ12) in which the catalytic subunit (EZH2) acts as a histone H3 lysine-27 methyltransferase, generating trimethylated histone H3 lysine-27 (H3K27me3), an epigenetic mark essential for programmed repression of gene expression. EZH2 is overexpressed in a wide range of human cancers and is considered a promising target for the development of anti-cancer therapies. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 333.8 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant proteins in 20 mM Tris-HCl, pH 7.9, 150 mM NaCl, 2 mM MgCl, 2 mM DTT, 20% glycerol (w/v), 0.01% NP-40 |
| Accession#: | NM_001203247, NM_001114176, NM_003797, NM_005610, NM_015355 |
| Tag: | Flag & His |
| Protein Length: | EZH2 2-746, AEBP2 2-517, EED 2-441, RbAp48 2-425, SUZ12 2-739; All full-length |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0006 | GSK343 | Inquiry |
| BSM-0059 | 3-Deazaneplanocin A | Inquiry |
| BSM-0060 | 3-Deazaneplanocin A hydrochloride | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0024 | Recombinant Human EZH1 293 Cell Lysate | Inquiry |
| EL-0025 | Recombinant Human EZH2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| ezh1 | EZH2 | ||
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