| Cat.No.: | PE-3030 |
| Product Name: | PRMT1 Methyltransferase |
| Description: | PRMT1, a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an w-nitrogen of the guanidino function of protein L-arginine residues (w-monomethylation) and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA). A ubiquitously expressed protein and the major source of histone H4 arginine-3 methylation (H4R3me1, H4R3me2a), PRMT1 also methylates other histones and numerous other substrates, accounting for about 85% of all arginine methylation in mammalian cells. PRMT1 is essential to oncogenic transformation in mixed lineage leukemia (MLL), interacting with the MLL-EEN fusion protein in a transcription-activating complex also comprising histone acetyltransferase activity. Methylation of Arg-260 in estrogen receptor a (ERa) by PRMT1 is required for its interaction with p85 and src and ERa hypermethylation is associated with a subset of breast cancers. There is also evidence suggesting a role for elevated PRMT1 activity in heart disease and asthma. These various disease connections have made PRMT1 the target of recent HTS and drug discovery efforts. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 68.3 kDa |
| Formulation: | Solution of purified recombinant protein in 25 mM Na2HPO4, 4.4 mM KH2PO4, pH 7.4, 137 mM NaCl, 2.7 mM KCl, 3 mM DTT, 30% (w/v) glycerol. |
| Accession#: | NM_001536 |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 2-371 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| BSM-0047 | SGC707 | Inquiry |
| ◆ Antibodies | ||
| EAb-0048 | PRMT6 Polyclonal Antibody | Inquiry |
| EAb-0049 | PRMT7 Polyclonal Antibody | Inquiry |
| EAb-0050 | PRMT1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| Pr-SET7 | PRC1 | PRC2 | PRDM1 |
| PRDM10 | PRDM11 | PRDM12 | PRDM13 |
| PRDM14 | PRDM15 | PRDM16 | PRDM17 |
| PRDM2 | PRDM3 | PRDM4 | PRDM5 |
| PRDM6 | PRDM7 | PRDM8 | PRDM9 More > |
| PREP1 | PRIM2 | PRKAA2 | PRKCA |
| PRKCB | PRKCE | PRKDC | PRKRIP1 |
| PRMT | prmt1 | PRMT2 | PRMT3 |
| PRMT5 | prmt6 | PRMT7 | PRMT8 |
| PRMT9 | Progerin | Protamine 2 | Prox1 |
| PRPF31 | PRPF40A | PRSS12 | PRSS55 |
| PRTFDC1 | |||
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