Cat.No.: | PE-3078 |
Product Name: | Histone H2B |
Description: | Full-length, untagged human recombinant histone H2B expressed in E. coli. One of the four, core nucleosomal histones, H2B forms dimers with histone H2A, two of which associate with the H3-H4 tetramer (H3-H4)2, forming the core octamer of the nucleosome. Histone H2B is subject to several regulatory post-translational modifications including monoubiquitination, phosphorylation, acetylation, lysine methylation and crotonylation. Monoubiquitination of H2B lysine-120 (H2BK120ub) stimulates H3K4 methylation in chromatin, an effect which recent evidence suggests is mediated in trans via ubiquitin binding by Ash2L, a component of the human MLL/SET1 family methyltransferase complexes. Monoubiquitination at both H2BK34 and H2BK120 has been shown to enhance H3K79 methylation by Dot1L. |
Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
Molecular Weight: | 13.9 kDa |
Species: | Human |
Formulation: | Solution of purified recombinant protein in 50 mM HEPES/NaOH pH 7.1, 10 mM KCl, 1 mM DTT, 1 mM EDTA, 10% glycerol (v/v). |
Accession#: | NM_0080593 |
Expression System: | E. coli |
Protein Length: | 1-126 |
Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Product Types | ||
◆ Nucleosomes | ||
NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
◆ Synthetic Peptides | ||
SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
SP-0010 | Histone H4 peptide (1-21) | Inquiry |
SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
Related Gene / Proteins | |||
HIC1 | HIF1A | HIF1AN | HINFP |
HIPK1 | HIPK2 | HIRA | Histone |
Histone H1 | Histone H2A | Histone H2B | Histone H3 |
Histone H4 | HIV-1 reverse transcriptase |
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