| Cat.No.: | PE-3148 |
| Product Name: | BRDT-2 (His) |
| Description: | Human recombinant BRDT, bromodomain-2. BRDT, like other human members of the BET family of chromatin-binding proteins (BRD2, BRD3, BRD4), comprises two bromodomains, protein modules that bind e-N-acetyllysine residues. Expression of BRDT is testis-specific and deletion of the mouse BRDT-1 (bromodomain 1) causes abnormal spermatid development and sterility. BRDT’s functions in spermiogenesis include roles in broad, programmatic regulation of gene expression, mRNA splicing, chromatin remodeling, meiosis, formation of the chromocenter and post-meiotic genome repackaging. A three-month treatment of male mice with the BET family bromodomain inhibitor, JQ1, reversibly eliminated fertility, highlighting the potential of BRDT-specific inhibition as an approach for pharmacologic male contraception. The structure of the mouse BRDT-2 in complex with a histone H3 K18Ac peptide has been determined. The experimental atherosclerosis drug and BET family bromodomain inhibitor RVX-208 is selective for the second bromodomains of this group, including BRDT-2. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 18.6 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant protein in 50 mM HEPES/NaOH, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol |
| Accession#: | NM_001242806 |
| Tag: | His |
| Protein Length: | 272-383 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
