| Cat.No.: | PE-3222 |
| Product Name: | BPTF-[PHD-BRD] (GST) |
| Description: | Human recombinant BPRF bromodomain expressed in E. Coli with an N-terminal GST tag. Full-length BPTF is a DNA and histone-binding component of NURF nucleosome remodeling complex. This construct comprises BPTF's second PHD zinc-finger, which primarily binds histone H3K4me3 and adjacent bromodomain , which has binding affinity for various histone tail acetyllysines, including H4 K5Ac, K12Ac and K16Ac. BPTF expression is elevated in developing neurons, but also in neuronal tissue under various neurodegenerative conditions. Amplification of the BPTF-coding chromosomal locus is prevalent in various cancers and knockdown of BPTF restricts proliferation in cultured cells with an engineered pre-malignant phenotype. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 50.26 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris-HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v) |
| Accession#: | NM_182641 |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 2722-2920 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0035 | Human BPTF Knockout Cell Line 8bp deletion | Inquiry |
| CL-0484 | Human BPTF Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0544 | BPTF/FALZ TR-FRET Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1698 | FALZ (BPTF), GST-tag | Inquiry |
| PE-1701 | FALZ (BPTF), His-tag | Inquiry |
| Related Gene / Proteins | |||
| BPTF | |||
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