| Cat.No.: | PE-3252 |
| Product Name: | DNMT3b |
| Description: | DNMT3b, a de novo DNA methyltransferase, is essential in development and can mediate gene silencing. Overexpression and/or gene amplification of DNMT3b, along with DNA hypermethylation, have been observed in a number of cancers, suggesting that DNMT3b is an oncogene and a promising therapeutic target. For example, DNMT3b expression and DNA methylation are elevated in a subset of breast cancers and both specific knockdown of DNMT3b expression and chemical inhibition of DNMTs enhance the sensitivity of breast cancer lines with this hypermethylation phenotype to cytotoxic chemotherapy agents. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 121.6 kDa |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris/HCl pH 8.0, 150 mM NaCl, 3 mM DTT, 10% glycerol (v/v). |
| Accession#: | NM_006892 |
| Tag: | GST |
| Protein Length: | 2-853 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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