| Cat.No.: | PE-3280 |
| Product Name: | BRG1 / SMCA4 Bromodomain |
| Description: | Recombinant human BRG1 Bromodomain (Brahma-related gene 1, SMC4A, SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4, accession number P51532 amino acids 1441 to 1580) containing an N-terminal GST tag, expressed in E. coli. BRG1 / SMCA4 is an ATP-dependent chromatin remodeling protein and a component of several protein complexes involved in transcriptional activation, including CREST and BAF. BRG1 is a component of an embryonic stem cell-specific BAF complex, and BRG1 is essential for ESC self-renewal and proliferation. Mutations in the BRG1 gene have been described in a large number of primary tumors, especially lung cancer. The bromodomain in BRG1 has been reported to bind multiple sites of histone acetylation, with particular preference for H3 acetylated at lysine 14 (H3K14Ac). |
| Applications: | Recombinant BRG1 / SMCA4 Bromodomain is useful for protein binding and screening experiments examining acetylated protein substrates. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 41 kDa |
| Species: | Human |
| Formulation: | 20 mM Tris-HCl pH 8.0, 200 mM NaCl, 1 mM DTT, 20% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0080 | AZ-505 ditrifluoroacetate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0120 | BRG1 bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 More > |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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